Kenan AYDOĞAN, Hayriye SARICAOĞLU, Emel BÜLBÜL BAŞKAN, Serkan YAZİCİ, Özge ZORLU

Cyclosporine-A for severe childhood atopic dermatitis: clinical experience on efficacy and safety profile

Background/aim: Management of atopic dermatitis (AD) in children is still challenging. The aim of this study was to evaluate theefficacy and safety profile of cyclosporine-A (CsA) treatment in children with severe and recalcitrant AD.Materials and methods: Medical records of 43 children followed between January 2010 and December 2015 and treated with systemicCsA were evaluated retrospectively. Treatment efficacy was assessed according to the physician’s global assessment (PGA) score.According to the treatment response, patients were grouped as nonresponder, moderate responder, or good responder. Effects of thevariables on treatment response were evaluated by analysis of variance (ANOVA). The safety profile of CsA was assessed by clinical andlaboratory findings at each visit.Results: The median initial dose of CsA was 3 mg/kg daily, ranging between 2.5 and 5 mg/kg daily. The mean duration of CsA therapywas 4.9 ± 4.24 months. Seventeen patients (39.5%) achieved good response in a treatment period of 3 to 14 months. After discontinuationof CsA, of the 17 patients, relapse was observed in 4 (23.5%). Moderate response was observed in 12 (27.9%) patients; however, 14 (32.6)patients did not respond to the treatment. Five patients reported mild side effects.Conclusion: Low-dose CsA seems to be an effective and safe treatment option for severe and recalcitrant AD in children.

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