Clinical, neuroradiological, and electroencephalographic findings of reflex epilepsies
Background/aim: Reflex seizures are defined as epilepsies with seizures induced by a specific afferent stimulus or patient activity alone or in combination with spontaneous seizures, and/or accompanied by photoparoxysmal response on electroencephalogram (EEG). The aim of this study is to review and analyze clinical, neuroradiological, and EEG findings in reflex epilepsies. Materials and methods: The records of 1598 follow-up patients out of 2237 patients who had been examined between July 1995 and August 2017 were analyzed retrospectively. Results: Eighty of 1598 patients had reflex epilepsy and 72 of those patients had seizures induced by visual stimuli. Considering the somatosensory stimuli, in one patient it was associated with eating while in 7 patients it was associated with hot water. The results of neurological examination were normal in 90% while cranial imaging was normal in 82.5% of the patients. Only 53 of 80 patients' EEGs revealed pathological EEG findings. Furthermore, in 43 patients, the most frequently prescribed drug was valproate. Conclusion: In this hospital-based study, reflex epilepsy frequency was 5% and cranial imaging was mostly found to be normal, as stated in the literature. However, patient histories revealed an unexpectedly high rate of head trauma before seizure onset and a family history of epilepsy.
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- Panayiotopoulos CP. The Epilepsies: Seizures, Syndromes and
Management. Oxford, UK: Bladon Medical Publishing; 2005.
- Engel J. A proposed diagnostic scheme for people with epileptic
seizures and with epilepsy: report of the ILAE Task Force on
Classification and Terminology. Epilepsia 2001; 42: 796-803.
- Baysal L, Bebek N, Baykan B. Fotosensitivite ve refleks
epilepsiler. Epilepsi 2014; 20: 23-31 (in Turkish).
- Bozdemir H, Aslan K. Reflex epilepsies. Archives Medical
Review Journal 2009; 18: 70-90.
- Engel J, Pedley TA, Aicardi J. Epilepsy: A Comprehensive
Textbook. Philadelphia, PA, USA: Lippincott Williams &
Wilkins; 2008.
- Panayiotopoulos CP. A Clinical Guide to Epileptic Syndromes
and Their Treatment: Based on the New ILAE Diagnostic
Scheme. Oxford, UK: Bladon Medical Publishing; 2002.
- Ritaccio AL. Reflex seizures. Neurol Clin 1994; 12: 57-84.
- Fisher RS, Harding G, Erba G, Barkley GL, Wilkins A. Photic-
and pattern-induced seizures: a review for the Epilepsy
Foundation of America Working Group. Epilepsia 2005; 46:
1426-1441.
- Verrotti A, Trotta D, Salladini C, di Corcia G, Chiarelli F.
Topical review: photosensitivity and epilepsy. J Child Neurol
2004; 19: 571-578.
- Harding G, Harding P. Televised material and photosensitive
epilepsy. Epilepsia 1999; 40: 65-69.
- Politi-Elishkevich K, Kivity S, Shuper A, Levine H, Goldberg-
Stern H. Idiopathic photosensitive occipital epilepsy: clinical
and electroencephalographic (EEG) features. J Child Neurol
2014; 29: 307-311.
- Wolf P, Goosses R. Relation of photosensitivity to epileptic
syndromes. J Neurol Neurosur Ps 1986; 49 :1386-1391.
- Appleton R, Beirne M, Acomb B. Photosensitivity in juvenile
myoclonic epilepsy. Seizure 2000; 9 :108-111.
- Shiraishi H, Fujiwara T, Inoue Y, Yagi K. Photosensitivity in
relation to epileptic syndromes: a survey from an epilepsy
center in Japan. Epilepsia 2001; 42: 393-397.
- Xue LY, Ritaccio AL. Reflex seizures and reflex epilepsy. Am J
Electroneurod T 2006; 46: 39-48.
- Harding G, Wilkins AJ, Erba G, Barkley GL, Fisher RS. Photic-
and Pattern-induced seizures: expert consensus of the Epilepsy
Foundation of America Working Group. Epilepsia 2005; 46:
1423-1425.
- Satishchandra P. Hot-water epilepsy. Epilepsia 2003; 44: 29-32.
- Grosso S, Farnetani MA, Francione S, Galluzzi P, Vatti G,
Cordelli DM, Morgese G, Balestri P. Hot water epilepsy and
focal malformation of the parietal cortex development. Brain
Dev-Jpn 2004; 26: 490-493.
- Satishchandra P, Shivaramakrishana A, Kaliaperumal V,
Schoenberg BS. Hot-water epilepsy: a variant of reflex epilepsy
in southern India. Epilepsia 1988; 29: 52-56.
- Patel M, Satishchandra P, Aravinda H, Bharath RD, Sinha S.
Hot water epilepsy: phenotype and single photon emission
computed tomography observations. Ann Indian Acad Neur
2014; 17: 470.
- Satishchandra P, Dilipkumar S, Subbakrishna D, Sinha S.
Intermittent clobazam prophylaxis in hot water epilepsy is
safe and effective: a prospective study. Epilepsy Res 2014; 108:
1238-1242.
- Nagaraja D, Chand RP. Eating epilepsy. Clin Neurol Neurosur
1984; 86: 95-99.
- Özözen Ayas Z, Bölük A. Nadir bir refleks epilepsi türü: yemek
yeme epilepsisi. Epilepsi 2017; 23: 81-83 (in Turkish).