Coxiella burnetii seroprevalence in the rural part of Bolu, Turkey*

Aim: This study was performed to determine the seroprevalence of Coxiella burnetii in the rural part of Bolu, a city located in the western part of the Black Sea region of Turkey. Materials and Methods: The study population was chosen by cluster sampling to represent the rural population of the city. Serum samples were collected from the 9 rural districts of Bolu. Blood samples were taken to the laboratory while stored at 4 °C in ice-cooled boxes. The sera were then stored at -20 °C until testing. The presence of IgG antibodies against C. burnetii phase-II antigens in the sera was determined using IFA. Results: The study included 293 cases and C. burnetii phase-II IgG was positive in 61 of the subjects (20.8%). The seroprevalence of C. burnetii was 23.8% (59/248) among the participants above 18 years of age and 4.4% (2/45) among those younger than 18 years of age (P < 0.01). There was a significant relationship between C. burnetii seropositivity and direct contact with the birth products of farm animals (P < 0.001); however, there was not a significant difference between genders. Conclusions: Although the seroprevalence rate was high, Q fever was underreported and unrecognized in rural Bolu. We conclude that Q fever must be considered in patients with a suitable clinical course in this region.

Anahtar Kelimeler:

Key words: Coxiella burnetii, seroprevalence, Bolu, Turkey

Coxiella burnetii seroprevalence in the rural part of Bolu, Turkey*

Keywords:

Key words: Coxiella burnetii, seroprevalence, Bolu, Turkey,

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Eyigör M, Kırkan Ş, Gültekin B, Yaman S, Tekbıyık S, Aydın N. Q Humması İçin Risk Gruplarında Coxiella burnetii’ye Karşı Oluşan Antikorların Elısa Ve Ifa Testleri İle Saptanması Turkish Journal of Infection 2006; 20: 31-36
Seyitoglu S, Ozkurt Z, Dınler U, Okumuş B. The Seroprevalence of Coxiellosis in Farmers and Cattle in Erzurum District in Turkey. Turk J Vet Anim Sci 2006; 30: 71-75.
Maltezou HC, Raoult D. Q fever in children. Lancet Infect Dis 2002; 2: 686-691.
Tissot Dupont H, Raoult D, Brouqui P, Janbon F, Peyramond D, Weiller PJ, Chicheportiche C, Nezri M, Poirier R. Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients: 323 French cases. Am J Med 1992; 93: 427-434.
Ergonul O, Ergonul O, Zeller H, Kılıç S, Kutlu S, Kutlu M, Cavusoglu S, Esen B, Dokuzoguz B. Zoonotic infections among veterinarians in Turkey: Crimean-Congo hemorrhagic fever and beyond. Int J Infect Dis 2006; 10: 465-469.
Fishbein DB, Raoult D. A cluster of Coxiella burnetii infections associated with exposure to vaccinated goats and their unpasteurized dairy products. Am J Trop Med Hyg 1992; 47: 35-40.
Pinsky RL, Fishbein DB, Greene CR, Gensheimer KF. An outbreak of cat-associated Q fever in the United States. J Infect Dis 1991; 164: 202-204.
Hatchette TF, Hudson RC, Schlech WF, Campbell NA, Hatchette JE, Ratnam S, Raoult D, Donovan C, Marrie TJ. Goat- associated Q fever: a new disease in Newfoundland. Emerg Infect Dis 2001; 7: 413-419.