Zekeriya ÖZTEMÜR, Emine Elif ALTUNTAŞ, Umut Hatay GÖLGE, Hatice ÖZER, Okay BULUT

Comparing extracorporeal shock wave and hyaluronic acid in a rabbit cartilage defect model: the effects of ESW on cartilage defect

To compare the efficiency of extracorporeal shock wave (ESW) treatment with hyaluronic acid (HA) viscosupplementation in an experimental rabbit cartilage defect model. Materials and methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups: HA, ESW, ESW + HA, and control. Chondral defects were created in the left knees of the rabbits. HA viscosupplementation was performed on the HA and ESW + HA groups, and after 24 h, 0.16 mJ/mm2 ESW was performed on the ESW and ESW + HA groups. After an 8-week follow-up, the rabbits were sacrificed and histopathological examination of the defects was carried out. In addition, immunohistochemistry was performed by the avidin-biotin peroxidase method using vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-beta 1), and type II collagen antibodies, and the results were evaluated semiquantitatively. Results: There was a significant difference between the control group and the ESW group in terms of Pineda score and type II collagen expression; between the control group and the HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression; and between the control group and the ESW + HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression. Conclusion: The results show that both treatment methods have positive therapeutic effects on the articular cartilage defect model in terms of the parameters studied.

Anahtar Kelimeler:

Key words: ESW, HA, cartilage defect, VEGF, TGF-beta 1, type II collagen

Comparing extracorporeal shock wave and hyaluronic acid in a rabbit cartilage defect model: the effects of ESW on cartilage defect

Keywords:

Key words: ESW, HA, cartilage defect, VEGF, TGF-beta 1, type II collagen,

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