Osman Metin İPÇİOĞLU, Mustafa GÜLTEPE, Ömer ÖZCAN

Cobalamin Deficiency During Pregnancy Expressed as Elevated Urine Methylmalonic Acid Levels Determined by a Photometric Assay

Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We aimed to evaluate cobalamin state in pregnancy by using urine MMA levels determined by an economic spectrophotometric method. Materials and Methods: For this cross-sectional study, plasma total homocysteine (tHcy), serum folate and vitamin B12, and urine MMA levels were measured in 186 uncomplicated pregnant women (30 in first, 58 in second and 98 in third trimester). MMA measurements were made in first morning urine samples with normalizing by creatinine concentrations. Results: The tHcy concentrations were not elevated (

Anahtar Kelimeler:

Cobalamin deficiency, pregnancy, urine MMA

Cobalamin Deficiency During Pregnancy Expressed as Elevated Urine Methylmalonic Acid Levels Determined by a Photometric Assay

Keywords:

Cobalamin deficiency, pregnancy, urine MMA,

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