Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience

Background/aim: Carfilzomib (CFZ) is a new-generation proteasome inhibitor with significant activity in relapsed or refractory multiple myeloma (R/R-MM). We have retrospectively evaluated R/R-MM patients who were treated with CFZ plus dexamethasone. Materials and methods: Twenty-one R/R-MM patients who were treated with CFZ plus dexamethasone between October 2013 and January 2016 were screened. The patients were followed until March 2016 after CFZ treatment. Results: Ten (47.6%) of the patients were female and 11 (52.4%) of them were male. The median age was 62 (47-76) years. The median number of prior treatment lines was 3 (2-7). The median number of administered cycles of treatment for CFZ was 4 (1-10). The median overall response rate was 26.3%. The most common hematological adverse events were anemia and thrombocytopenia (38%). The most common nonhematological adverse event was fatigue (71.4%). One patient died because of a cerebrovascular event and 1 patient died because of pneumonia during the treatment period. The median duration of response rate and time to next therapy were 8 (7-9) and 3 (2-16) months, respectively. The median overall survival was 8 (0.5-33) months. Conclusion: Despite the small number of patients, our results suggest that CFZ provides acceptable responses in heavily pretreated R/R-MM patients.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

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Müçteba Enes YAYLA, Ufuk İLGEN, Nurşen DÜZGÜN

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Merih Güray DURAK, Pınar BALCI, Süleyman Özkan AKSOY, Ali İbrahim SEVİNÇ

Bedside measurement of the optic nerve sheath diameter with ultrasound in cerebrovascular disorders

Emine AKÇAY, Havva ŞAHİN KAVAKLI, Sema YÜZBAŞIOĞLU, Yücel YÜZBAŞIOĞLU, Selçuk COŞKUN, Tolga ÖZ, Refik KUNT, Sinan BECEL, Ferhat İÇME

Emine DEMİREL, Sefa KELEKÇİ, Emre EKMEKCİ, Mustafa ŞENGÜL, Raziye İRİ, Melahat ATASEVER