Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience

Öz Background/aim: Carfilzomib (CFZ) is a new-generation proteasome inhibitor with significant activity in relapsed or refractory multiple myeloma (R/R-MM). We have retrospectively evaluated R/R-MM patients who were treated with CFZ plus dexamethasone. Materials and methods: Twenty-one R/R-MM patients who were treated with CFZ plus dexamethasone between October 2013 and January 2016 were screened. The patients were followed until March 2016 after CFZ treatment. Results: Ten (47.6%) of the patients were female and 11 (52.4%) of them were male. The median age was 62 (47-76) years. The median number of prior treatment lines was 3 (2-7). The median number of administered cycles of treatment for CFZ was 4 (1-10). The median overall response rate was 26.3%. The most common hematological adverse events were anemia and thrombocytopenia (38%). The most common nonhematological adverse event was fatigue (71.4%). One patient died because of a cerebrovascular event and 1 patient died because of pneumonia during the treatment period. The median duration of response rate and time to next therapy were 8 (7-9) and 3 (2-16) months, respectively. The median overall survival was 8 (0.5-33) months. Conclusion: Despite the small number of patients, our results suggest that CFZ provides acceptable responses in heavily pretreated R/R-MM patients.

Kaynak Göster

Bibtex @ { tbtkmedical576468, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2018}, volume = {48}, pages = {80 - 83}, doi = {}, title = {Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience}, key = {cite}, author = {Uysal, Ayşe and Soyer, Nur Akad and Özkan, Melda and Şahin, Fahri and Vural, Filiz and Töbü, Mahmut and Tombuloğlu, Murat and Saydam, Güray} }
APA Uysal, A , Soyer, N , Özkan, M , Şahin, F , Vural, F , Töbü, M , Tombuloğlu, M , Saydam, G . (2018). Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience . Turkish Journal of Medical Sciences , 48 (1) , 80-83 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45691/576468
MLA Uysal, A , Soyer, N , Özkan, M , Şahin, F , Vural, F , Töbü, M , Tombuloğlu, M , Saydam, G . "Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience" . Turkish Journal of Medical Sciences 48 (2018 ): 80-83 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/45691/576468>
Chicago Uysal, A , Soyer, N , Özkan, M , Şahin, F , Vural, F , Töbü, M , Tombuloğlu, M , Saydam, G . "Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience". Turkish Journal of Medical Sciences 48 (2018 ): 80-83
RIS TY - JOUR T1 - Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience AU - Ayşe Uysal , Nur Akad Soyer , Melda Özkan , Fahri Şahin , Filiz Vural , Mahmut Töbü , Murat Tombuloğlu , Güray Saydam Y1 - 2018 PY - 2018 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 80 EP - 83 VL - 48 IS - 1 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience %A Ayşe Uysal , Nur Akad Soyer , Melda Özkan , Fahri Şahin , Filiz Vural , Mahmut Töbü , Murat Tombuloğlu , Güray Saydam %T Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience %D 2018 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 48 %N 1 %R %U
ISNAD Uysal, Ayşe , Soyer, Nur Akad , Özkan, Melda , Şahin, Fahri , Vural, Filiz , Töbü, Mahmut , Tombuloğlu, Murat , Saydam, Güray . "Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience". Turkish Journal of Medical Sciences 48 / 1 (Şubat 2018): 80-83 .
AMA Uysal A , Soyer N , Özkan M , Şahin F , Vural F , Töbü M , Tombuloğlu M , Saydam G . Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience. Turkish Journal of Medical Sciences. 2018; 48(1): 80-83.
Vancouver Uysal A , Soyer N , Özkan M , Şahin F , Vural F , Töbü M , Tombuloğlu M , Saydam G . Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience. Turkish Journal of Medical Sciences. 2018; 48(1): 80-83.
IEEE A. Uysal , N. Soyer , M. Özkan , F. Şahin , F. Vural , M. Töbü , M. Tombuloğlu ve G. Saydam , "Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience", Turkish Journal of Medical Sciences, c. 48, sayı. 1, ss. 80-83, Şub. 2018

16839 14670

Arşiv
Sayıdaki Diğer Makaleler

Effects of nefopam with fentanyl in intravenous patient-controlled analgesia after arthroscopic orthopedic surgery: a prospective double-blind randomized trial

You Na OH, Kyu Nam KIM, Mi Ae JEONG, Dong Won KIM, Ji Yoon KIM, Hyun Seo KI

Biofilm formation in uropathogenic Escherichia coli: association with adhesion factor genes

Hojjatolah ZAMANI, ALI SALEHZADEH

Advantages of b-mode ultrasound combined with strain elastography in differentiation of idiopathic granulomatous mastitis from malignant breast lesions

Serdar ARSLAN, Fatih ÖNCÜ, M. Ali ERYILMAZ, Mehmet Sedat DURMAZ, Ayşegül ALTUNKESER, Yaşar ÜNLÜ

Carfilzomib experience in relapsed/refractory multiple myeloma: a single-center experience

Ayşe UYSAL, Nur Akad SOYER, Melda ÖZKAN, Fahri ŞAHİN, Filiz VURAL, Mahmut TÖBÜ, Murat TOMBULOĞLU, Güray SAYDAM

HIV infection and poor renal outcomes following noncardiac surgery

Yoshan MOODLEY

Translocation breakpoints of chromosome 3 in male carriers: a report of twelve cases and a review of the literature

Hongguo ZHANG, Ruixue WANG, Nn LI, Haibo ZHU, Hao ZHANG, Ruizhi LIU

Validity and reliability of the Turkish version of the DSM-5 Generalized Anxiety Disorder Severity Scale for children aged 11-17 years

Şermin Yalin SAPMAZ, Handan Özek ERKURAN, Dilek ERGİN, Masum ÖZTÜRK, Nesrin Şen CELASİN, Duygu KARAARSLAN, Ömer AYDEMİR

Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats

AKIN BODUR, Cemil KAHRAMAN, Diler Us ALTAY, Taghi Ahmadi RENDI, AHMET MENTEŞE, Ahmet ALVER

Retinopathy of prematurity in extremely premature infants: multiple births versus single births

İkbal Seza PETRİÇLİ, Caner KARA, Nihal DEMİREL, Dilek Ulubaş IŞIK, Ahmet Yağmur BAŞ

Evaluation of urinary incontinence and quality of life in married women aged between 20 and 49 years (Sakarya, Turkey)

Kevser İLÇİOĞLU, Sevil ŞAHİN, Nebahat ÖZERDOĞAN, Alaettin ÜNSAL