The effect of total intravenous anesthesia on the postoperative cognitive functions of young and elderly patients after lumbar disk surgery

The negative effects of surgery and anesthesia on cognitive functions and their relationships with many factors are well known. In the present study we aimed to investigate the effect of the total intravenous anesthesia (TIVA) method on the postoperative cognitive functions between young and elderly patients scheduled to undergo lumbar disk surgery. Materials and methods: The TIVA method was applied to 40 patients less than 65 years old (young, Group Y) and => 65 years old (old, Group O), whose Mini Mental State Examination (MMSE) results and serum S-100 beta protein levels were compared preoperatively and postoperatively at the 24th hour. Results: Postoperative cognitive dysfunction was not observed in any of the groups in the early stage. MMSE results and mean S-100 beta protein levels determined before and after the operation did not have statistically significant differences between the groups over time. Conclusion: In the present study, the TIVA method did not affect postoperative early cognitive functions in either old or young patients who underwent lumbar disk surgery.

The effect of total intravenous anesthesia on the postoperative cognitive functions of young and elderly patients after lumbar disk surgery

The negative effects of surgery and anesthesia on cognitive functions and their relationships with many factors are well known. In the present study we aimed to investigate the effect of the total intravenous anesthesia (TIVA) method on the postoperative cognitive functions between young and elderly patients scheduled to undergo lumbar disk surgery. Materials and methods: The TIVA method was applied to 40 patients less than 65 years old (young, Group Y) and => 65 years old (old, Group O), whose Mini Mental State Examination (MMSE) results and serum S-100 beta protein levels were compared preoperatively and postoperatively at the 24th hour. Results: Postoperative cognitive dysfunction was not observed in any of the groups in the early stage. MMSE results and mean S-100 beta protein levels determined before and after the operation did not have statistically significant differences between the groups over time. Conclusion: In the present study, the TIVA method did not affect postoperative early cognitive functions in either old or young patients who underwent lumbar disk surgery.

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  • Ward B, Imarengiaye C, Peirovy J, Chung F. Cognitive function is minimally impaired after ambulatory surgery. Can J Anesth 2005; 52: 1017–1021.
  • Caverni V, Rosa G, Pinto G, Tordiglione P, Favaro R. Hypotensive anesthesia and recovery of cognitive functions in long-term craniofacial surgery. J Craniofac Surg 2005; 16: 531–536.
  • Nishikawa K, Nakayama M, Omote K, Namiki A. Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients; propofol- based vs. sevoflurane-based anesthesia. Acta Anaesthesiol Scand 2004; 48: 162–168.
  • Magni G, Baisi F, La Rosa I, Imperiale C, Fabbrini V, Pennacchiotti ML, Rosa G. No difference in emergence time and early cognitive function between sevoflurane–fentanyl and propofol–remifentanil in patients undergoing craniotomy for supratentorial intracranial surgery. J Neurosurg Anesthesiol 2005; 17: 134–138.
  • Kostopanagiotou G, Markantonis SL, Polydorou M, Pandazi A, Kottis G. Recovery and cognitive function after fentanyl or remifentanil administration for carotid endarterectomy. J Clin Anesth 2005; 17: 16–20.
  • Heizmann CW, Cox JA. New perspectives on S100 proteins: a multi-functional Ca(2+)-, Zn(2+)- and Cu(2+)-binding protein family. Biometals 1998; 11: 383–397.
  • Linstedt U, Meyer O, Kropp P, Berkau A, Tapp E, Zenz M. Serum concentration of S-100 protein in assessment of cognitive dysfunction after general anesthesia in different types of surgery. Acta Anaesthesiol Scand 2002; 46: 384–389.
  • Böttiger BW, Möbes S, Glätzer R, Bauer H, Gries A, Bärtsch P, Motsch J, Martin E. Astroglial protein S-100 is an early and sensitive marker of hypoxic brain damage and outcome after cardiac arrest in humans. Circulation 2001; 103: 2694–2698.
  • Raabe A, Menon DK, Gupta S, Czosnyka M, Pickard JD. Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot study. J Neurol Neurosurg Psychiatry 1998; 65: 930–932.
  • Rasmussen LS, Christiansen M, Hansen PB, Moller JT. Do blood levels of neuron-specific enolase and S-100 protein reflect cognitive dysfunction after coronary artery bypass? Acta Anaesthesiol Scand 1999; 43: 495–500.
  • Grichnik KP,  Ijsselmuiden AJ,  D’Amico TA,  Harpole DH Jr, White WD, Blumenthal JA, Newman MF. Cognitive decline after major noncardiac operations: a preliminary prospective study. Ann Thorac Surg 1999; 68: 1786–1791.
  • Parikh SS, Chung F. Postoperative delirium in the elderly. Anesth Analg 1995; 80: 1223–1232.
  • Canet J,  Raeder J,  Rasmussen LS,  Enlund M,  Kuipers HM, Hanning CD, Jolles J, Korttila K, Siersma VD, Dodds C et al. Cognitive dysfunction after minor surgery in the elderly. Acta Anaesthesiol Scand 2003; 47: 1204–1210.
  • Monk TG, Weldon BC, Garvan CW, Dede DE,  Van der Aa MT, Heilman KM, Gravenstein JS. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 2008; 108: 18–30.
  • Chung F, Seyone C, Dyck B, Chung A, Ong D, Taylor A, Stone R. Age-related cognitive recovery after general anesthesia. Anesth Analg 1990; 71: 217–24.
  • Wu CL, Hsu W, Richman JM, Raja SN. Postoperative cognitive function as an outcome of regional anesthesia and analgesia. Reg Anesth Pain Med 2004; 29: 257–268.
  • Ozkose Z,  Ercan B,  Unal Y,  Yardim S,  Kaymaz M,  Dogulu F, Pasaoglu A. Inhalation versus total intravenous anesthesia for lumbar disc herniation: comparison of hemodynamic effects, recovery characteristics, and cost. J Neurosurg Anesthesiol 2001; 13: 296–302.
  • Hanning C. Postoperative cognitive dysfunction. Br J Anaesth 2005; 95: 82–87.
  • Bekker AY, Weeks EJ. Cognitive function after anaesthesia in the elderly. Best Pract Res Clin Anaesthesiol 2003; 17: 259–272.
  • Schütz C, Stover JF, Thompson HJ, Hoover RC, Morales DM, Schouten JW, McMillan A, Soltesz K, Motta M, Spangler Z et al. Acute, transient hemorrhagic hypotension does not aggravate structural damage or neurologic motor deficits but delays the long-term cognitive recovery following mild to moderate traumatic brain injury. Crit Care Med 2006; 34: 492–501.
  • Kubitz J, Epple J, Bach A, Motsch J, Martin E, Schmidt H. Psychomotor recovery in very old patients after total intravenous or balanced anesthesia for cataract surgery. Br J Anaesth 2001; 86: 203–208.
  • Moffat A, Cullen PM. Comparison of two standard techniques of general anaesthesia for day-case cataract surgery. Br J Anaesth 1995; 74: 145–148.
  • Rasmussen LS. Postoperative cognitive dysfunction: incidence and prevention. Best Pract Res Clin Anaesthesiol 2006; 20: 315–330.
  • Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Standardize mini mental test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi 2002; 13: 273– 281 (in Turkish).
  • Boos GL, Soares LF, Oliveıra Fılho GR. Postoperative cognitive dysfunction: prevalence and associated factors. Rev Bras Anestesiol 2005; 55: 517–524.
  • Gunaydin B, Babacan A. Cerebral hypoperfusion after cardiac surgery and anesthetic strategies: a comparatıve study with high dose fentanyl and barbiturate anesthesia. Ann Thorac Cardiovasc Surg 1998; 4: 12–17.
  • Petzold A,  Green AJ,  Keir G,  Fairley S,  Kitchen N,  Smith M, Thompson EJ. Role of serum S100B as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit Care Med 2002; 30: 2706–2710.
  • Grocott HP, Croughwell ND, Amory DW, White WD, Kirchner JL, Newman MF. Cerebral emboli and serum S100β during cardiac operations. Ann Thorac Surg 1998; 65: 1645–1649.
  • Svenmarker S, Sandström E, Karlsson T, Aberg T. Is there an association between release of protein S100B during cardiopulmonary bypass and memory disturbance? Scand Cardiovasc J 2002; 36: 117–122.
  • Linstedt U, Meyer O, Kropp P, Berkau A, Tapp E, Zenz M. Serum concentration of S-100 protein in assessment of cognitive dysfunction after general anesthesia in different types of surgery. Acta Anaesthesiol Scand 2002; 46: 384–389.
  • Rasmussen LS, Christiansen M, Eliasen K, Sander-Jensen K, Moller JT. Biochemical markers for brain damage after cardiac surgery-time profile and correlation with cognitive dysfunction. Acta Anaesthesiol Scand 2002; 46: 547–551.
  • Fong HK, Sands LP, Leung JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg 2006; 102: 1255–1266.
  • Ng KF, Yuen TS, Ng VM. A comparison of postoperative cognitive function and pain relief with fentanyl or tramadol patient-controlled analgesia. J Clinic Anesth 2006; 18: 205– 210.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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The effect of total intravenous anesthesia on the postoperative cognitive functions of young and elderly patients after lumbar disk surgery

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