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• 1. Hassell TM. Phenytoin: gingival overgrowth. In: Hassell TM ed Epilepsy and the oral manifestations of phenytoin therapy. S Karger, Basel, Switzerland, 1981: 116-137.
• 2. Seymour RA, Thomason JM, Ellis JS. The pathogenesis of drug-induced gingival overgrowth. J Clin Periodont 1996; 23: 165-175.
• 3. Foster R, Hassell TM. Response of single cell clones of human gingival fibroblasts to phenytoin in vitro. J Dent Res 1985; 64: 289.
• 4. Dill RE, Miller EK, Weil T, Lesley S, Farmer GR, Iacopino AM. Phenytoin increases gene expression for plateletderived growth factor B chain in macrophages and monocytes. J Periodontol 1993; 64: 169-173.
• 5. Iacopino AM, Doxey D, Christopher WC, et al. Phenytoin and cyclosporine A specifically regulate macrophage phenotype and expression of plateletderived growth factor and interleukin-1 in vitro and in vivo: possible molecular mechanism of drug-induced gingival hyperplasia. J Periodontol 1997; 68: 73-83.
• 6. Dinarello CA. Biology of interleukin-1. The FASEB Journal 1988; 2: 108-115.
• 7. Smith JA, Mizel SB, Cohen D, Gree IRA. Interleukin 1, a potential regulator of fibroblast proliferation. J Immunol 1982; 128: 2177-2182
• 8. Bartold PM. The effect of interleukin-1b on proteoglycans synthesised by human gingival fibroblasts in vitro. Connect Tissue Res 1988; 23: 287-304.
• 9. Hirano T, Akira S, Taga T, Kishimoto T. Biological and clinical aspects of interleukin-6. Immunol Today 1990; 11: 443-449.
• 10. Le J, Vilcek J. Interleukin-6: A multifactorial cytokine regulating immune reactions and the acute phase response. Lab Invest 1989; 61: 588- 602.
• 11. Vilcek J, Kohase M, Henriksen- DeStefano D. Mitogenic effect of double-stranded RNA in human fibroblasts: role of autogenous interferon. J Cell Phys 1987; 130: 37- 43.
• 12. YŸcel-Lindberg T, Lerner UH, Modeer T. Effects and interactions of tumour necrosis factor a and bradykinin on interleukin-1 production in gingival fibroblasts. J Periodont Res 1995; 30: 186-191.
• 13. Modeer T, Brunius G, Iinuma M, Lerner UH. Phenytoin potentiates interleukin-1 induced prostaglandin biosynthesis in human gingival fibroblasts. Bri J Pharma 1992; 106: 574-578.
• 14. Modeer T, Anduren I, Bengtsson A, Andersson G. Interleukin-1b and phenytoin reduce a1(I) procollagen mRNA expression in human gingival fibroblasts. J Periodont Res 1996; 3: 563-568.
• 15. Silness J, Lše H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odont Scand 1964; 22: 121-135.
• 16. Saxer UP, MŸhleman HR. Motivation und aufklarung. Sch MZZ 1975; 85: 905-919.
• 17. Pernu HE, Pernu LM, Huttunen KR, Nieminen PA, Knuuttila MLE. Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. J Periodontol 1992; 63: 548-553.
• 18. Angelopoulos AP, Goaz BS. Incidence of diphenyl-hydantoin gingival hyperplasia. J Oral Surg 1972; 34: 898-906.
• 19. Reinhardt RA, Masada MP, Johnson GK, DuBois LM, Seymour GJ, Allison AC. IL- 1 in gingival crevicular fluid following closed root planing and papillary flap debridment. J Clin Periodont 1993; 20: 514-519.
• 20. Tsai CC, Ho YP, Chen CC. Levels of interleukin-1 beta and interleukin-8 in gingival crevicular fluids in adult periodontitis. J Periodontol 1995; 66: 852-859.
• 21. Lamster IB, Celenti RS, Jans HH, Fine JB, Grbic JT. Current status of tests for periodontal disease. Adv Dent Res 1993; 7: 182-190
• 22. Dahllšf G, Modeer T, Reinholt FB, Wikstršm B, Hjerpe A. Proteoglycans and glycosaminoglycans in phenytoininduced gingival overgrowth. J Periodont Res 1986; 21: 13-21.
• 23. Brunius G, YŸcel-Lindberg T, Shinoda K, Modeer T. Effect of phenytoin on interleukin-1b production in human gingival fibroblasts challenged to tumour necrosis factor a in vitro. Eur J Oral Sci 1996; 104: 27-33.
• 24. Atilla G, KŸtŸkŸler N. Crevicular fluid interleukin-1b, tumour necrosis factor- a, and interleukin-6 levels in renal transplant patients receiving cyclosporine A. J Periodontol 1998; 69: 784-790.
• 25. McLaughlin WS, Ball DE, Seymour RA, Kamali F, White K. The pharmacokinetics of phenytoin in gingival crevicular fluid and plasma in relation to gingival overgrowth. J Clin Periodont 1995; 22: 942-945.
• 26. Ball DE, McLaughlin WS, Seymour RA, Kamali F. Plasma and saliva concentrations of phenytoin and 5-(4- hydroxyphenyl)-5-phenylhydantoin in relation to the incidence and severity of phenytoin-induced gingival overgrowth in epileptic patients. J Periodontol 1996; 67: 597-602.
• 27. Marshall RI, Bartold PM. Medication induced gingival overgrowth. Oral Dis 1998; 4: 130-151