Fatma Kavak AKELMA, İlkay Baran AKKUŞ, Savaş ALTINSOY, Derya ÖZKAN, Jülide ERGİL

The effects of pregabalin and adductor canal block on postoperative pain in arthroscopic anterior cruciate ligament reconstruction

Background/aim: To determine the effectiveness of pregabalin and adductor canal block on opioid consumption, postoperative pain, and fast-tracking.Materials and methods: A total of 51 American Society of Anaesthesiologists ASA classification I-II patients aged 18-70 years who were scheduled to undergo elective anterior cruciate ligament reconstruction were included in the study. Patients were randomized into groups P, A, and C. Patients in group P n = 16 , received 150 mg of preoperative oral pregabalin, patients in group A n = 17 received postoperative adductor canal blockade, and patients in group C n = 18 received neither adductor canal block nor pregabalin. Surgeries were performed under spinal anaesthesia with hyperbaric bupivacaine following monitorization. Demographic data along with block features, hemodynamic data, mean opioid consumption, numerical rating scale score, White's fast-track score, and postoperative adverse effects were recorded.Results: Fifty-seven patients were enrolled in the study, and 6 patients were excluded from the study; the data of 51 patients were included in the final analyses. Demographic characteristics and hemodynamic data were similar between the 3groups. Postoperative opioid consumption was significantly lower in groups A and P compared with group C group P = 178.75 mg, group C = 318.61 mg, group A = 236.47 mg; P 0.05 . The rate of postoperative adverse effects was similar between the groups P > 0.05 .Conclusion: Preoperative pregabalin 150 mg reduced postoperative opioid consumption as much as adductor canal block in patients undergoing anterior cruciate ligament reconstruction. The first analgesic requirement was earlier in group C than in groups P and A. In addition, pregabalin can prolong the duration of spinal sensory block and shorten the time required to achieve high fast-tracking scores. We recommend the use of both methods as a part of multimodal analgesia.

Keywords:

Pregabalin, adductor canal block, postoperative pain,

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