Tevhid AYDIN, Ruhuşen KUTLU, Hayriye BALTAOĞLU ALP, İbrahim KILINC

Aşırı Kilolu/Obez Bireylerde Akupunktur Ve Diyetin Serum Leptin Ve Nesfatin-1 Düzeylerine Etkisi

Akupunktur uygulamaları ve diyet obezite tedavisinde sıklıkla kullanılmaktadır. Sunulan çalışmada aşırı kilolu ve/veya obez bireylerde akupunktur ve diyet öncesi/sonrasında ölçülen serum leptin ve nesfatin-1 düzeylerindeki değişiklikleri araştırmayı amaçladık. Bu müdahele çalışması 90 kilolu/obez hasta üzerinde yapıldı. Katılımcılar üç gruba ayrıldı: Grup 1 (Akupunktur), Grup 2 (Diyet) ve Grup 3 (Kilo vermek için herhangi bir girişimde bulunmamış olanlar- kontrol grubu). Müdahale öncesi ve sonrası serum leptin ve nesfatin-1 düzeyleri ölçüldü. Akupunktur grubunda 30. gün leptin değerleri anlamlı olarak azaldı (p=0.040), 3. grupta ise anlamlı olarak arttı (p=0.039). Nesfatin-1 değerlerinin hem akupunktur (p=0.032), hem de diyet (p=0.017) gruplarında anlamlı olarak arttığı saptandı. Ayrıca vücut ağırlıkları hem akupunktur (p=0.032) hem de diyet gruplarında (p<0.001) anlamlı olarak azaldı. Sonuçlarımız akupunktur tedavisinin iştah hormonları üzerindeki etkilerini desteklemektedir. Yakın zamanda keşfedilen leptin ve nesfatin-1 hormonlarının endojen ve ekzojen etkilerinin mekanizmaları hakkında daha fazla araştırmaya ihtiyaç vardır.

Anahtar Kelimeler:

Akupunktur, Diyet, Leptin, Obezite., Nesfatin-1

The Effect of Acupuncture and Diet on Serum Leptin and Nesfatin-1 Levels in Overweight/Obese Individuals

Acupuncture applications and diet are frequently used in obesity treatment. We aimed to investigate the changes in serum leptin and nesfatin-1 levels measured before and after acupuncture and diet in overweight/obese individuals in the presented study. This interventional study was carried out on 90 overweight/obese patients. Participants were divided into three groups: Group 1 (Acupuncture), Group 2 (Diet), and Group 3 (Those who did not take any attempts to lose weight- control group). Serum leptin and nesfatin-1 levels were measured before and after the intervention. The 30th days leptin values were significantly decreased in the acupuncture group (p=0.040) while they were significantly increased in the control group (p=0.039). It was detected that the nesfatin-1 values were significantly increased in both acupuncture (p=0.032) and diet groups (p=0.017). Also, body weights significantly decreased both in acupuncture (p=0.032) and diet groups (p<0.001). Our results support the effects of acupuncture treatment on appetite hormones. Further research on the mechanisms of endogenous and exogenous actions of the recently discovered hormones, leptin and nesfatin-1, are needed.

Keywords:

Acupuncture Diet, Leptin, Leptin, Nesfatin-1, Obesity,

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