Improving the sensitivity and accuracy of microcantilever biosensors by a truss structure within air medium
Improving the sensitivity and accuracy of microcantilever biosensors by a truss structure within air medium
Early diagnosis is a very fundamental issue in treating most diseases and for this purpose microcantileversare very effective and reliable devices. In this work, four models of biosensor-based microcantilever are compared anda novel design with high sensitivity, quality factor, and accuracy is proposed. A truss structure is designed near theanchored end of the microcantilever, which improves the sensitivity in order to increase detection accuracy. A linearrelationship between resonance frequency shift and masses has been estimated for all the designs. High quality factor,which increases the accuracy of measurement, is taken into account as the other benefit of the proposed design. Thesemicrocantilevers can be used as an array for multiple early diagnosis of cancer and moreover these features will improveclinical applications of cantilever sensors for early disease diagnosis
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- Huber F, Lang HP, Backmann N, Rimoldi D, Gerber C. Direct detection of a BRAF mutation in total RNA from
melanoma cells using cantilever arrays. Nat Nanotechnol 2013; 8: 125-129.
- Lu L, Si J. C., Gao Z. F., Zhang Y, Lei J. L., Luo H. Q., Li N. B. Highly selective and sensitive electrochemical
biosensor for ATP based on the dual strategy integrating the cofactor-dependent enzymatic ligation reaction with
self-cleaving DNAzyme-amplified electrochemical detection. Biosens Bioelectron 2015; 63: 14-20.
- Park J, Karsten SL, Nishida S, Kawakatsu H, Fujita H. Application of a new microcantilever biosensor resonating
at the air–liquid interface for direct insulin detection and continuous monitoring of enzymatic reactions. Lab Chip
2012; 12: 4115- 4119.
- Bai X, Hou H, Zhang B, Tang J. Label-free detection of kanamycin using aptamer-based cantilever array sensor.
Biosens Bioelectron 2014; 56: 112-116.
- Huang LS, Pheanpanitporn Y, Yen YK, Chang KF, Lin LY, Lai DM. Detection of the antiepileptic drug phenytoin
using a single free-standing piezoresistive microcantilever for therapeutic drug monitoring. Biosens Bioelectron 2014;
59: 233-238.
- Datar R, Kim S, Jeon S, Hesketh P, Manalis S, Boisen A, Thundat T. Cantilever sensors: nanomechanical tools for
diagnostics. Mrs Bull 2009; 34: 449-454.
- McKendry R, Zhang J, Arntz Y, Strunz T, Hegner M, Lang HP, Baller MK, Certa U, Meyer E, Güntherodt HJ et
al. Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array. P
Natl Acad Sci USA 2002; 99: 9783-9788.
- Calleja M, Tamayo J, Johansson A, Rasmussen P, Lechuga LM, Boisen A. Polymeric cantilever arrays for biosensing
applications. Sensor Lett 2003; 1: 20-24.
- Cakmak O, Ermek E, Kilinc N, Yaralioglu GG, Urey H. Precision density and viscosity measurement using two
cantilevers with different widths. Sensor Actuat A-Phys 2015; 232: 141-147.
- Zhang W, Turner K. Frequency dependent fluid damping of micro/nano flexural resonators: experiment, model and
analysis. Sensor Actuat A-Phys 2007; 134: 594-599.
- Wang J, Wang L, Zhu Y, Zhang J, Liao J, Wang S, Yang J, Yang F. A high accuracy cantilever array sensor for
early liver cancer diagnosis. Biomed Microdevices 2016; 18: 110.
- Vančura C, Dufour I, Heinrich SM, Josse F, Hierlemann A. Analysis of resonating microcantilevers operating in a
viscous liquid environment. Sensor Actuat A-Phys 2008; 141: 43-51.
- Bao M. Analysis and Design Principles of MEMS Devices. Shanghai, China: Elsevier, 2005.
- Rowell D. Review of First-and Second-Order System Response. Report, MIT, 2004.
- Wang L, Chai S, Yoo D, Gan L, Ng K. PID and Predictive Control of Electrical Drives and Power Converters Using
MATLAB/Simulink. Singapore: Wiley, 2015.
- Chang CC, Yang RJ. Computational analysis of electrokinetically driven flow mixing in microchannels with patterned blocks. J Micromech Microeng 2004; 14: 550.
- Blom FR, Bouwstra S, Elwenspoek M, Fluitman JH. Dependence of the quality factor of micromachined silicon
beam resonators on pressure and geometry. J Vac Sci Technol B 1992; 10: 19-26.
- Sader JE. Frequency response of cantilever beams immersed in viscous fluids with applications to the atomic force
microscope. J Appl Phys 1998; 84: 64-76.