Deep learning-based COVID-19 detection system using pulmonary CT scans

Deep learning-based COVID-19 detection system using pulmonary CT scans

One of the most significant pandemics has been raised in the form of Coronavirus disease 2019 (COVID19). Many researchers have faced various types of challenges for finding the accurate model, which can automatically detect the COVID-19 using computed pulmonary tomography (CT) scans of the chest. This paper has also focused on the same area, and a fully automatic model has been developed, which can predict the COVID-19 using the chest CT scans. The performance of the proposed method has been evaluated by classifying the CT scans of community-acquired pneumonia (CAP) and other non-pneumonia. The proposed deep learning model is based on ResNet 50, named CORNet for the detection of COVID-19, and also performed the retrospective and multicenter analysis for the extraction of visual characteristics from volumetric chest CT scans during COVID-19 detection. Between August 2016 and May 2020, the datasets were obtained from six hospitals. Results are evaluated on the image dataset consisting of a total of 10,052 CT scan images generated from 7850 patients, and the average age of the patients was 50 years. The implemented model has achieved the sensitivity and specificity of 90% and 96%, per scanned image with an AUC of 0. 95.

___

  • [1] WHO, “Getting your workplace ready for COVID-19,” World Heal. Organ., 2020
  • [2] Bolay H, Gül A, Baykan B. COVID-19 is a Real Headache!. Headache 2020; 60 (7):1415-1421, doi.org/10.1111/head.13856
  • [3] Xing-Yi Ge, Jia-Lu Li, Xing-Lou Yang, Aleksei A. Chmura, Guangjian Zhu et al. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor Nature, 2013; 503:535–538, doi:10.1038/nature12711
  • [4] Flor J. Surviving COVID-19 Pneumonia At Home: COVID Case #1906. Philipp. J. Otolaryngol. Head Neck Surg. 2020; 35 (1) doi:10.32412/pjohns.v35i1.1259
  • [5] Tao A, Zhenlu Y, Hongyan H, Chenao Z, Chong C et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology 2020; 296 (2):E32-E40, doi: 10.1148/radiol.2020200642
  • [6] Corman Victor M, Landt O, Kaiser M, Molenkamp R, Meijer A et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance 2020; 25(3):pii=2000045. doi:10.2807/1560- 7917.ES.2020.25.3.2000045
  • [7] Harsono IW, Liawatimena S, Cenggoro TW. Lung nodule detection and classification from Thorax CT-scan using RetinaNet with transfer learning. Journal of King Saud University - Computer and Information Sciences., 2020 doi:10.1016/j.jksuci.2020.03.013
  • [8] Shah V, Keniya R, Shridharani A, Punjabi M, Shah J et al. Diagnosis of COVID-19 using CT scan images and deep learning techniques. Emergency Radiology 2020; 28: 497–505, doi:10.1007/s10140-020-01886-y
  • [9] Wang S, Kang B, Ma J, Zeng X, Xiao M et al. A deep learning algorithm using CT images to screen for Corona Virus Disease (COVID-19). European Radiology 2020; 31: 6096–6104, doi:10.1007/s00330-021-07715-1
  • [10] NCT04396067, Combination With Inhibitor of Neutrophil Elastase (All-trans Retinoic Acid ) and Isotretinoin May Enhances Neutralizing Antibodies in COVID -19 Infected Patients Better Than COVID-19 Inactivated Vaccines 2020. https://clinicaltrials.gov/show/NCT04396067, 2020.
  • [11] Apostolopoulos ID, Mpesiana TA. Covid-19: automatic detection from X-ray images utilizing transfer learning with convolutional neural networks. Physical and Engineering Sciences in Medicine 2020; 43: 635–640, doi:10.1007/s13246-020-00865-4
  • [12] Rajpurkar P, Irvin J, Ball RL, Zhu K. , Yang B et al. Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists. PLoS Medicine 2018; 15 (11): e1002686 doi:10.1371/journal.pmed.100268
  • [13] Alqudah AM, Qazan S, Alqudah A. Automated Systems for Detection of COVID-19 Using Chest X-ray Images and Lightweight Convolutional Neural Networks. Research Square 2020; doi:10.21203/rs.3.rs-24305/v12020
  • [14] Singh N, Aggarwal AN, Gupta D, Behera D, Jindal SK. Unchanging clinico-epidemiological profile of lung cancer in North India over three decades. Cancer Epidemiology 2010; 34 (1): 101-104, doi:10.1016/j.canep.2009.12.015
  • [15] Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM et al. Dermatologist-level classification of skin cancer with deep neural networks. Nature 2017; 542: 115–118, doi:10.1038/nature21056
  • [16] Liu J, Liu J, Liu Y, Yang R, Lv D et al. A locating model for pulmonary tuberculosis diagnosis in radiographs. arXiv 2019.
  • [17] Butt C, Gill J, Chun D, Babu B. A Deep learning system to screen coronavirus disease 2019 pneumonia. Applied Intelligence 2020; doi:10.1007/s10489-020-01714-3
  • [18] Fanelli D, Piazza F. Analysis and forecast of COVID-19 spreading in China, Italy and France. Chaos, Solitons & Fractals 2020; 134 doi:10.1016/j.chaos.2020.109761
  • [19] Li L, Qin L, Xu Z, Yin Y, Wang X et al. Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT. Radiology 2020; 296:E65–E71, doi:10.1148/radiol.2020200905
  • [20] Chimmula VKR, Zhang L. Time series forecasting of COVID-19 transmission in Canada using LSTM networks. Chaos, Solitons and Fractals, 2020; 135 doi:10.1016/j.chaos.2020.109864
  • [21] Grewal M, Srivastava MM, Kumar P, Varadarajan S. RADnet: Radiologist level accuracy using deep learning for hemorrhage detection in CT scans in IEEE Proceedings - International Symposium on Biomedical Imaging, Washington, DC, USA, 2018.
  • [22] Gonzalez G, Ash SY, Ferrero GVS, Onieva JO, Rahghi FN et al. Disease staging and prognosis in smokers using deep learning in chest computed tomography. American Journal of Respiratory and Critical Care Medicine 2018; 197 (2): 193-203, doi: 10.1164/rccm.201705-0860OC
  • [23] Zhao W, Zhong Z, Xie X, Yu Q, Liu J. Relation between chest CT findings and clinical conditions of coronavirus disease (covid-19) pneumonia: A multicenter study. American Journal of Roentgenology 2020; 214 (5): 1072-1077, doi: 10.2214/AJR.20.22976
  • [24] Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA et al. Chest CT findings in coronavirus disease 2019 (COVID-19): Relationship to duration of infection. Radiology 2020; 295 (3) doi:10.1148/radiol.2020200463
  • [25] Yang X, He X, Zhao J, Zhang Y, Zhang S et al. COVID-CT-Dataset : A CT Image Dataset about COVID-19. arXiv 2020.
  • [26] Gozes O, Frid-Adar M, Greenspan H, Browning PD, Zhang H et al. Rapid AI development cycle for the coronavirus (COVID-19) pandemic: Initial results for automated detection & patient monitoring using deep learning CT image analysis. Radiology: Artificial Intelligence 2020.
  • [27] Wang X, Deng X, Fu Q, Zhou Q, Feng J et al. A Weakly-Supervised Framework for COVID-19 Classification and Lesion Localization From Chest CT. IEEE Transactions on Medical Imaging 2020; 39 (8): 2615-2625 doi: 10.1109/TMI.2020.2995965
  • [28] Fang Y, Zhang H, Xie J, Lin M, Ying L et al. “Sensitivity of chest CT for COVID-19: Comparison to RT-PCR,” Radiology 2020; 296 (2) doi:10.1148/radiol.2020200432
  • [29] Murphy K, Smits H, Knoops AGJ, Korst M, Samson T et al. COVID-19 on chest radiographs: A multireader evaluation of an artificial intelligence system. Radiology 2020; 296 (3):E166-E172 doi:10.1148/radiol.2020201874
  • [30] Farooq M, Hafeez A. COVID-ResNet: A deep learning framework for screening of COVID19 from radiographs. arXiv 2020, http://arxiv.org/abs/2003.14395
  • [31] Comelli A, Coronnello C, Dahiya N, Benfante V, Palmucci S et al. Lung Segmentation on High-Resolution Computerized Tomography Images Using Deep Learning: A Preliminary Step for Radiomics Studies. Journal of Imaging 2020; 6 (11): 125 doi: 10.3390/jimaging6110125
  • [32] DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach. Biometrics, 1988; 44 (3):837-45.
  • [33] Gupta B, Tiwari M, Lamba SS. Visibility improvement and mass segmentation of mammogram images using quantile separated histogram equalisation with local contrast enhancement. CAAI Transactions on Intelligence Technology 2019; 4 (6) doi: 10.1049/trit.2018.1006
  • [34] Alonso BF, Nixdorf DR, Shueb SS, John MT, Law AS et al. Examining the Sensitivity and Specificity of 2 Screening Instruments: Odontogenic or Temporomandibular Disorder Pain?. Journal of Endodontics 2017; 43 (1):36-45. doi: 10.1016/j.joen.2016.10.001
  • [35] Loey M, Smarandache F, Khalifa NEM. Within the lack of chest COVID-19 X-ray dataset: A novel detection model based on GAN and deep transfer learning. Symmetry 2020; 12 (4): 651 doi:10.3390/sym12040651
  • [36] Sitaula C, Hossain MB. Attention-based VGG-16 model for COVID-19 chest X-ray image classification. Applied Intelligence 2021; 51:2850–2863, doi:10.1007/s10489-020-02055-x
  • [37] Ucar F, Korkmaz D. COVID Diagnosis-Net: Deep Bayes-SqueezeNet based diagnosis of the coronavirus disease 2019 (COVID-19) from X-ray images. Medical Hypotheses, 2020; 140:109761. doi: 10.1016/j.mehy.2020.109761
  • [38] Ardakani AA, Kanafi AR, Acharya UR, Khadem N, Mohammadi A. Application of deep learning technique to manage COVID-19 in routine clinical practice using CT images: Results of 10 convolutional neural networks. Computers in Biology and Medicine 2020; 121, doi:10.1016/j.compbiomed.2020.103795
Turkish Journal of Electrical Engineering and Computer Sciences-Cover
  • ISSN: 1300-0632
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Deep learning-based COVID-19 detection system using pulmonary CT scans

Preeti SHARMA, Deepika KOUNDAL, Rumi Iqbal DOEWES, Rajit NAIR, Adi ALHUDHAIF

A deep transfer learning based model for automatic detection of COVID-19 from chest X-rays

Prateek CHHIKARA, Prakhar GUPTA, Prabhjot SINGH, Tarunpreet BHATIA

Brain tumor detection from MRI images with using proposed deep learning model: the partial correlation-based channel selection

Atınç YILMAZ

Attention-based end-to-end CNN framework for content-based X-ray image retrieval

Adi ALHUDHAİF, Kemal POLAT, Şaban ÖZTÜRK

New normal: cooperative paradigm for COVID-19 timely detection and containment using Internet of things and deep learning

FAROOQUE HASSAN KUMBHAR, SYED ALİ HASSAN, SOO YOUNG SHİN

Malignant skin melanoma detection using image augmentation by oversampling in nonlinear lower-dimensional embedding manifold

Olusola Oluwakemi ABAYOMI-ALLI, Robertas DAMAŠEVIČIUS, Sanjay MISRA, Rytis MASKELIŪNAS, Adebayo ABAYOMI-ALLI

Diagnosis of paroxysmal atrial fibrillation from thirty-minute heart rate variability data using convolutional neural networks

Resul KARA, Murat SURUCU, Yalcin ISLER

Attention augmented residual network for tomato disease detection and classification

KUMIE Gedamu, Getinet YILMA, Seid BELAY, Maregu ASSEFA, Melese AYALEW, Ariyo OLUWASANMI, Zhiguang QIN

Benchmarking of deep learning algorithms for skin cancer detection based on a hybrid framework of entropy and VIKOR techniques

Baidaa AL-BANDER, Rwayda KH. S.AL-HAMD, Qahtan M. YAS, Hussain MAHDI

MRI based genomic analysis of glioma using three pathway deep convolutional neural network for IDH classification

Sonal GORE, Jayant JAGTAP