Duygu DAYANIR, Hakan DAYANIR, Serdar GÜNAYDIN

Mitochondrial Transplantation and Transfer, from past to future expectations

Mitochondria, with their unique roles in cell energy metabolism, continue to be studied by years of research. Mitochondrial transfer can be summarized as the process of transferring isolated mitochondria to the damaged tissue. In this way, it is aimed to improve the mitochondrial dysfunction in areas with impaired mitochondrial functions such as heart damaged tissue. Although there are many studies on this subject, especially cardiomyocytes, the protective effects of the application in processes such as myocardial ischemia and reperfusion injury continues to be investigated. Although there are different procedures for transferring the isolated mitochondrin to the damaged tissue, many studies have reported positive results regarding the application. In this review, it is aimed to look at the subject from a wide window, while examining the studies done in this field in the literature.

Anahtar Kelimeler:

Mitochondrial transfer, Mitochondrial transplantation, Mitochondria

Mitokondri Nakli ve Transferi, geçmişten gelecek beklentilere

Hücre enerji eldesinde üstlendikleri eşsiz rolleri ile mitokondri yıllardır devam eden araştırmalar ile incelenmeye devam etmektedir. Mitokondriyal transfer hasarlanmış dokuya izole edilmiş olan mitokondrinin transfer edilme süreci olarak özetlenebilir. Bu sayede kalp hasarı olan doku gibi mitokondrial fonksiyonları bozulmuş bölgede mitokondrial disfonksiyon durmunun düzeltilmesi amaçlanmaktadır. Bu konu ile ilgili özellikle kalp dokusunda birçok çalışma olmakla beraber uygulanın miyokardial iskemi, reperfüzyon hasarı gibi süreçlerde koruyucu etkinliği araştırılmaya devam etmektedir. İzole edilen mitokondrin hasarlı dokuya aktarılmasında farklı prosedürler bulunmakla birlikte, birçok çalışmada uygulama ile ilgili olumlu sonuçlar bildirlmektedir. Derlemede literatürde bu alanda yapılmış olan çalışmalar incelenmekle birlikte konuya geniş bir penceren bakılması hedeflenmiştir.

Keywords:

Mitokondriyal transfer, Mitokondriyal transplantasyon, Mitokondri,

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