Deniz S. DOĞRUER, Şölen URLU, Tijen ÖNKOL

8891

Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 m g/mL) and E. coli (MIC ranging from 4 to 16 m g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 m g/mL.

Anahtar Kelimeler:

Pyridazine derivatives, antibacterial activity, antifungal activity.

Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 m g/mL) and E. coli (MIC ranging from 4 to 16 m g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 m g/mL.

Keywords:

Pyridazine derivatives, antibacterial activity, antifungal activity.,

Turkish Journal of Chemistry-Cover

ISSN: 1300-0527
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

Sayıdaki Diğer Makaleler

Influence of $AICI_3$ on the optical properties of new synthesized 3-armed poly(methyl methacrylate) films

Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Deniz S. DOĞRUER, Şölen URLU, Tijen ÖNKOL

Some bioactive organotin(IV) derivatives with 3,4-dichlorophenylacetic acid: synthesis, spectroscopic properties, and X-ray structure of [$Sn_4(C_4H_9)_8$(OOCC$H_2C_6H_3CI_2$)4O2 ]

Amin BADSHAH, Imtıaz Ud DIN, Bushra MIRZA, Muhammad Khawar RAUF, Muhammad Zaeem AKHTAR, Muhammad Adeel SAEED

Synthesis and characterization of new optically active polyamides containing 2-(4-nitro-1,3-dioxoisoindolin-2-yl)succinic acid and aromatic diamines via direct polycondensation

Khalil FAGHIHI, Morteza Absalar And Mohsen HAJIBEYGI

Influence of AlCl3 on the optical properties of new synthesized 3-armed poly(methyl methacrylate) films

Characterization of chitosan in acetic acid: Rheological and thermal studies

Esam A. EL-HEFIAN, Elham S. ELGANNOUDI, Azizah MAINAL

Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

Mahla TABESHNIA, Hossein HELI, Ali JABBARI

Density functional theory investigation of electrophilic addition reaction of chlorine to tricyclo[4.2.2.$2^{2,5}$ ]dodeca-1,5-diene

Rza ABBASOĞLU, Ahmet YAŞAR

Radical scavenging potential of compounds isolated from Vitex agnus-castus

Talat MAKHMOOR, - AZIZUDDIN, Muhammad İqbal CHOUDHARY

Study of catalytic activities of nanostructure copper and cobalt supported ZSM-5 catalysts for conversion of volatile organic compounds

Aligholi NIAEI, Dariush SALARI, Seyed Ali HOSSEINI