Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives

Öz Schiff base derivatives with anthracene- and pyrene-based units, Al-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 mu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity against all bacteria tested and both compounds were very well bound to CT-DNA. Density functional theory method with B3LYP/6-311++ G(d,p) basis set was performed to get information about the structural and electronic properties of the present compounds. In addition, the metal coordination properties of the dimers of the parent Schiff bases were investigated through interactions with Zn2+.

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Kaynak Göster

Bibtex @araştırma makalesi { tbtkchem945499, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2020}, volume = {44}, pages = {1200 - 1215}, doi = {}, title = {Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives}, key = {cite}, author = {Gumus, Aysegul and Okumus, Veysi and Gumus, Selcuk} }
APA Gumus, A , Okumus, V , Gumus, S . (2020). Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives . Turkish Journal of Chemistry , 44 (4) , 1200-1215 .
MLA Gumus, A , Okumus, V , Gumus, S . "Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives" . Turkish Journal of Chemistry 44 (2020 ): 1200-1215 <
Chicago Gumus, A , Okumus, V , Gumus, S . "Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives". Turkish Journal of Chemistry 44 (2020 ): 1200-1215
RIS TY - JOUR T1 - Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives AU - Aysegul Gumus , Veysi Okumus , Selcuk Gumus Y1 - 2020 PY - 2020 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 1200 EP - 1215 VL - 44 IS - 4 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2020 ER -
EndNote %0 Turkish Journal of Chemistry Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives %A Aysegul Gumus , Veysi Okumus , Selcuk Gumus %T Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives %D 2020 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 44 %N 4 %R %U
ISNAD Gumus, Aysegul , Okumus, Veysi , Gumus, Selcuk . "Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives". Turkish Journal of Chemistry 44 / 4 (Ağustos 2020): 1200-1215 .
AMA Gumus A , Okumus V , Gumus S . Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives. Turk J Chem. 2020; 44(4): 1200-1215.
Vancouver Gumus A , Okumus V , Gumus S . Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives. Turkish Journal of Chemistry. 2020; 44(4): 1200-1215.
IEEE A. Gumus , V. Okumus ve S. Gumus , "Synthesis, biological evaluation of antioxidant-antibacterial activities and computational studies of novel anthracene- and pyrene-based Schiff base derivatives", Turkish Journal of Chemistry, c. 44, sayı. 4, ss. 1200-1215, Ağu. 2020
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

9.8b 6.1b

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