Hany Mohamed HASSANIN, Magdy Ahmed IBRAHIM

7880

Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid

Chlorination, bromination, and condensation reactions of 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid (3) were studied. Some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c]quinolin-2(1H)-ones were also prepared. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.
Anahtar Kelimeler:

b-Ketoacid, 4-hydroxyquinolin-2(1H)-one, pyrano[3, 2-c]quinolinone, condensation reactions

Synthesis and antimicrobial activity of some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c] quinolinones from 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid

Chlorination, bromination, and condensation reactions of 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid (3) were studied. Some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c]quinolin-2(1H)-ones were also prepared. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.Pyranoquinolinones constitute the parent ring structure of pyranoquinoline alkaloids, which occur in the plant family Rutaceae. These pyranoquinoline alkaloids have gained considerable importance due to their pharmaceutical activities like anticoagulant, 1 coronary constricting, 2 and antifungal. 3 Pyrano[3,2-c]quinolinones were found to be active against certain immuno-reaction diseases, in particular against immediate hypersensitivity reactions (anaphylaxis). 4 
Keywords:

b-Ketoacid, 4-hydroxyquinolin-2(1H)-one, pyrano[3, 2-c]quinolinone, condensation reactions,

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Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
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