Chlorination, bromination, and condensation reactions of 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid (3) were studied. Some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c]quinolin-2(1H)-ones were also prepared. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.

Chlorination, bromination, and condensation reactions of 3-(1-ethy1-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-3-oxopropanoic acid (3) were studied. Some novel 4-hydroxyquinolin-2(1H)-ones and pyrano[3,2-c]quinolin-2(1H)-ones were also prepared. The structures of the novel compounds were established by elemental analyses and spectral data. All the products were also screened in vitro for their antimicrobial activity.Pyranoquinolinones constitute the parent ring structure of pyranoquinoline alkaloids, which occur in the plant family Rutaceae. These pyranoquinoline alkaloids have gained considerable importance due to their pharmaceutical activities like anticoagulant, 1 coronary constricting, 2 and antifungal. 3 Pyrano[3,2-c]quinolinones were found to be active against certain immuno-reaction diseases, in particular against immediate hypersensitivity reactions (anaphylaxis). 4