Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives

A series of 4-arylidenamino-4H-1,2,4-triazole derivatives (3-11) were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles (2) with certain aldehydes. Compounds 3-11 were reduced with NaBH4 to afford the corresponding 4-arylmethylenamino-4H-1,2,4-triazoles (12-20). Compounds 1-10 and 12-19 were characterized by elemental analyses and 1H NMR, 13C NMR, IR and UV spectral data. Compounds 11 and 20 were characterized by 1H NMR, 13C NMR, IR and mass spectral data. Compounds 14, 16, 17, and 18 were tested for anticancer activities. Compound 17, chosen for its higher anticancer activity in the preliminary tests with the cancer cell lines of MCF7, NCI-H460, and SF-268, exhibited remarkable anticancer potential in screening tests with 60 human cancer cell lines.

Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives

A series of 4-arylidenamino-4H-1,2,4-triazole derivatives (3-11) were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles (2) with certain aldehydes. Compounds 3-11 were reduced with NaBH4 to afford the corresponding 4-arylmethylenamino-4H-1,2,4-triazoles (12-20). Compounds 1-10 and 12-19 were characterized by elemental analyses and 1H NMR, 13C NMR, IR and UV spectral data. Compounds 11 and 20 were characterized by 1H NMR, 13C NMR, IR and mass spectral data. Compounds 14, 16, 17, and 18 were tested for anticancer activities. Compound 17, chosen for its higher anticancer activity in the preliminary tests with the cancer cell lines of MCF7, NCI-H460, and SF-268, exhibited remarkable anticancer potential in screening tests with 60 human cancer cell lines.

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Kaynak Göster

Bibtex @konferans bildirisi { tbtkchem142575, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2006}, volume = {30}, pages = {29 - 40}, doi = {}, title = {Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives}, key = {cite}, author = {Bekircan, Olcay and Kahveci, Bahittin and Küçük, Murat} }
APA Bekircan, O , Kahveci, B , Küçük, M . (2006). Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives . Turkish Journal of Chemistry , 30 (1) , 29-40 .
MLA Bekircan, O , Kahveci, B , Küçük, M . "Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives" . Turkish Journal of Chemistry 30 (2006 ): 29-40 <
Chicago Bekircan, O , Kahveci, B , Küçük, M . "Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives". Turkish Journal of Chemistry 30 (2006 ): 29-40
RIS TY - JOUR T1 - Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives AU - Olcay Bekircan , Bahittin Kahveci , Murat Küçük Y1 - 2006 PY - 2006 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 29 EP - 40 VL - 30 IS - 1 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Chemistry Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives %A Olcay Bekircan , Bahittin Kahveci , Murat Küçük %T Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives %D 2006 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 30 %N 1 %R %U
ISNAD Bekircan, Olcay , Kahveci, Bahittin , Küçük, Murat . "Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives". Turkish Journal of Chemistry 30 / 1 (Ocak 2006): 29-40 .
AMA Bekircan O , Kahveci B , Küçük M . Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives. Turk J Chem. 2006; 30(1): 29-40.
Vancouver Bekircan O , Kahveci B , Küçük M . Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives. Turkish Journal of Chemistry. 2006; 30(1): 29-40.
IEEE O. Bekircan , B. Kahveci ve M. Küçük , "Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives", Turkish Journal of Chemistry, c. 30, sayı. 1, ss. 29-40, Oca. 2006