Spectroscopic characterization and biological applications of organotin (IV) derivatives of 3-(N-naphthylaminocarbonyl)-2-propenoic acid
Spectroscopic characterization and biological applications of organotin (IV) derivatives of 3-(N-naphthylaminocarbonyl)-2-propenoic acid
In an effort to develop new organotin materials for investigation and biocidal evaluation, a series of compounds with the general formula $R_{4_n}SnL_n$ (where R = $CH_3$, $n-C_4H_9$, $C_6H_5$, $C_6H_5CH_2$ and L = 3-(N-naphthylaminocarbonyl)-2-propenoic acid) were synthesised, and characterised by elemental analysis, IR, multinuclear ($^1H$, $^{13}C$ and $^{119 }Sn$) NMR, $^{119m}Sn$ Mössbauer spectroscopy and mass spectrometry. The biological activity of these compounds against various bacteria and fungi was investigated. All of the compounds were active against the fungi tested with a few exceptions. These compounds also showed significant antibacterial activity. $LD_{50}$ data show that the investigated compounds have significant toxicity.
___
- 1. N. Nath, S. Pokharia and R. Yadav, Coord. Chem. Rev. 215, 99 (2001).
- 2. M. Gielen, Coord. Chem. Rev. 151, 41 (1996).
- 3. E.R.T. Tiekink, Trends Organomet. Chem. 1, 71 (1994).
- 4. M. Mazhar, M.A. Choudhary, S. Ali, X.Q. Lan and S. Xueqing, J. Chem. Soc. Pak. 23, 103 (2001).
- 5. L. Pellerito and L. Nagy, Coord. Chem. Rev. 224, 111 (2002).
- 6. V. Chandrasekhar, S. Nagendran and V. Baskar,Coord. Chem. Rev. 235, 1 (2002).
- 7. Sadiq-ur-Rehman, K. Shahid, S Ali, M. H. Bhatti and M. Parvez, J. Organomet. Chem. 690, 1396 (2005).
- 8. S. Mahmood, S. Ali, M.H. Bhatti, K. Shahid, S. Shahzadi, M. Mazhar, K.M. Khan and G.M. Maharvi, J. Chem. Soc. Pak. 26, 61 (2004).
- 9. S. Mahmood, S. Ali, M.H. Bhatti, M. Mazhar, K. Shahid, K.M. Khan and G.M. Maharvi, Turk. J. Chem. 28, 17 (2004).
- 10. M. Parvez, S. Ahmed, S. Ali, M.H. Bhatti and M. Mazhar, Acta Cryst. E60, m554 (2004).
- 11. M. Parvez, S. Ahmed, S. Ali, M.H. Bhatti and M. Mazhar, Acta Cryst. E60, m190 (2004).
- 12. S. Ahmed, S. Ali, F. Ahmed, M.H. Bhatti, A. Badshah, M. Mazhar and K.M. Khan, Synth. React. Inorg. Met.-Org. Chem. 32, 1521 (2002).
- 13. S. Shahzadi, M.H. Bhatti, K. Shahid, S. Ali, S.R. Tariq, M. Mazhar and K.M. Khan, Monatsh. Chem. 133,1089 (2002).
- 14. K. Shahid, S. Ali, M.H. Bhatti, M. Mazhar, S. Mahmood and S. Rehman, Turk. J. Chem. 26, 589 (2002).
- 15. M.H. Bhatti, S. Ali, H. Masood, M. Mazhar and S.I. Qureshi, Synth. React. Inorg. Met.-Org. Chem. 30, 1715 (2000).
- 16. S. Xueqing, Y. Zhiqiang, X. Qinglan and Li Jinshan, J. Organomet. Chem. 566, 103 (1998).
- 17. S. Ali, M. Danish, M.H. Bhatti, M. Mazhar and S. Mahmood, Pak. J. Sci. Ind. Res. 44, 194 (2001).
- 18. B. Wrackmeyer, Annu. Rep. NMR Spectrosc. 38, 203 (1999).
- 19. M.H. Bhatti, S. Ali, M. Mazhar, M. Danish and M.A. Choudhary, Turk. J. Chem. 23, 329 (1999).
- 20. S. Shahzadi, K. Shahid, S. Ali and M.H. Bhatti, J. Chem. Soc. Pak. 26, 395 (2004).
- 21. S.S. Shaukat, N.A. Khan and F. Ahmad, Pak. J. Bot. 12, 97 (1980).
- 22. B.N. Meyer, N.R. Ferrigni, J.E. Putman, L.B. Jacobson, D.E. Nichols and J.L. McLanghlin, Planta Med. 45, 31 (1982).
- 23. K. Sisido, Y. Yakeda and Z. Kingawa, J. Am. Chem. Soc. 83, 583 (1961).
- 24. D.D. Perrin and W.L.F. Armergo, Purification of Laboratory Chemicals, 3rd edition, Pergamon, Oxford,1988.