Spectroscopic Characterisation and Biological Applications of Organotin(IV) Derivatives of 3-(N-Naphthylaminocarbonyl)-2-propenoic Acid

In an effort to develop new organotin materials for investigation and biocidal evaluation, a series of compounds with the general formula R4 - nSnLn (where R = CH3, n-C4H9, C6H5, C6H5CH2 and L = 3-(N-naphthylaminocarbonyl)-2-propenoic acid) were synthesised, and characterised by elemental analysis, IR, multinuclear (1H, 13C and 119Sn) NMR, 119mSn Mössbauer spectroscopy and mass spectrometry. The biological activity of these compounds against various bacteria and fungi was investigated. All of the compounds were active against the fungi tested with a few exceptions. These compounds also showed significant antibacterial activity. LD50 data show that the investigated compounds have significant toxicity.

Anahtar Kelimeler:

Organotin(IV) carboxylates, biological studies, spectroscopic studies

Spectroscopic Characterisation and Biological Applications of Organotin(IV) Derivatives of 3-(N-Naphthylaminocarbonyl)-2-propenoic Acid

Keywords:

Organotin(IV) carboxylates, biological studies, spectroscopic studies,

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The1H and13C NMR spectra were recorded on a Bruker ARX 250 Spectrometer (Germany), using CDCl3 as an internal reference [δ1H(CDCl3= 7.24 : δ13C(CDCl3) = 77.0].119Sn NMR spectra were obtained with Me4Sn as external reference [Ξ (Sn) = 37.290665].119mSn M¨ossbauer spectra were obtained with a constant acceleration microprocessor controlled spectrometer (Cryoscopic Ltd., Oxford, UK); a barium stannate source was used at room temperature, and samples were packed in Perspex discs and cooled to 77
K. Isomer shift data are relative to SnO2. Mass spectral data were measured on a MAT 8500 Finnigan 70 eV mass spectrometer (Germany). The m/z values were evaluated assuming that H =1, C = 12, N = 14 and Sn = 120. Synthesis of ligand
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