Xinnan WANG, Jieshan QIU, Xinmin LI, Chun LIU

Palladium-catalyzed ligand-free and efficient Suzuki{Miyaura reaction ofN-methyliminodiacetic acid boronates in water

A green and efficient protocol has been developed for the Pd(OAc)2-catalyzed ligand-free Suzuki{Miyaurareaction ofN-methyliminodiacetic acid (MIDA) boronates in water. In the presence of Pd(OAc)2as a catalyst and(i-Pr)2NH as a base, the cross-coupling reactions of aryl bromides with aryl MIDA boronates proceeded smoothly inwater without any surfactant, and various functional groups were tolerated under the optimized conditions.

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