Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods

Mixture experimental design was used to enhance the separation selectivity of metal ions in nonaqueous capillary electrophoresis. The separation of cations (Ag, Fe, Cr, Mn, Cd, Co, Pb, Ni, Zn and Cu) was achieved using imidazole as UV co-ion for indirect detection. Acetic acid was chosen as an electrolyte because its cathodic electroosmotic flow permits faster separation. The composition of organic solvents is important to achieve the best separation of all metal ions. Simplex lattice design and response surface methods have proved to be an effective tool to optimize the composition of organic solvents in nonaqueous capillary electrophoresis. Full and reduced experimental design models were compared to obtain the optimum composition of solvents. Contour plots were presented to visualize the effect of the selected solvents on electrophoretic mobility. The highest electrophoretic mobilities were obtained with higher percentages of acetonitrile for all metal ions. Root mean square error (RMSE) and F-test were used to evaluate the models.

Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods

Mixture experimental design was used to enhance the separation selectivity of metal ions in nonaqueous capillary electrophoresis. The separation of cations (Ag, Fe, Cr, Mn, Cd, Co, Pb, Ni, Zn and Cu) was achieved using imidazole as UV co-ion for indirect detection. Acetic acid was chosen as an electrolyte because its cathodic electroosmotic flow permits faster separation. The composition of organic solvents is important to achieve the best separation of all metal ions. Simplex lattice design and response surface methods have proved to be an effective tool to optimize the composition of organic solvents in nonaqueous capillary electrophoresis. Full and reduced experimental design models were compared to obtain the optimum composition of solvents. Contour plots were presented to visualize the effect of the selected solvents on electrophoretic mobility. The highest electrophoretic mobilities were obtained with higher percentages of acetonitrile for all metal ions. Root mean square error (RMSE) and F-test were used to evaluate the models.

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Kaynak Göster

Bibtex @ { tbtkchem142563, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2006}, volume = {30}, pages = {181 - 192}, doi = {}, title = {Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods}, key = {cite}, author = {Demir, Cevdet and Yücel, Yasin} }
APA Demir, C , Yücel, Y . (2006). Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods . Turkish Journal of Chemistry , 30 (2) , 181-192 .
MLA Demir, C , Yücel, Y . "Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods" . Turkish Journal of Chemistry 30 (2006 ): 181-192 <
Chicago Demir, C , Yücel, Y . "Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods". Turkish Journal of Chemistry 30 (2006 ): 181-192
RIS TY - JOUR T1 - Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods AU - Cevdet Demir , Yasin Yücel Y1 - 2006 PY - 2006 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 181 EP - 192 VL - 30 IS - 2 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Chemistry Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods %A Cevdet Demir , Yasin Yücel %T Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods %D 2006 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 30 %N 2 %R %U
ISNAD Demir, Cevdet , Yücel, Yasin . "Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods". Turkish Journal of Chemistry 30 / 2 (Şubat 2006): 181-192 .
AMA Demir C , Yücel Y . Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods. Turk J Chem. 2006; 30(2): 181-192.
Vancouver Demir C , Yücel Y . Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods. Turkish Journal of Chemistry. 2006; 30(2): 181-192.
IEEE C. Demir ve Y. Yücel , "Optimization of the Nonaqueous Capillary Electrophoresis Separation of Metal Ions Using Mixture Design and Response Surface Methods", Turkish Journal of Chemistry, c. 30, sayı. 2, ss. 181-192, Şub. 2006