Novel surfactant stabilized PLGA cisplatin nanoparticles for drug delivery applications
Novel surfactant stabilized PLGA cisplatin nanoparticles for drug delivery applications
In the current study, cisplatin loaded (Poly(lactic-co-glycolicacid)) (PLGA) stabilized with 4-phenylphenacylbromide based surfactants nanoparticles were developed for drug delivery applications. For the course of this study four new 4-phenylphenacylbromide based compounds abbreviated as $PA(C_2 )_3 , PA(C_8 )_3 , PAC_{16}$ and PAC18 have been synthesized by the reaction of 4-phenylphenacylbromide with various long chain amines. The new surfactants were characterized with $^{1} H and ^{13}C NMR and FTIR spectroscopy. The critical micelle concentration (CMC) of newly synthesized surfactants are in the range of 0.024–0.091 mM. The newly synthesized surfactants have been incorporated in PLGA based nanoparticles and are used for drug encapsulation and delivery of cisplatin. The drug encapsulation efficiency for newly fabricated nanoparticles was found to be in the range of 65 ± 1.5 to 67 ± 1.6%, the drug loading was observed in the range of 1.96 ± 0.11 to 2.31 ± 0.19%, whereas the maximum drug release was found to be 85.1 ± 1.1%.
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- 1. Rosen MJ, Kunjappu JT. Surfactants and Interfacial Phenomena, 4th Edition. John Wiley & Sons Ltd, New York 2012. doi: 10.1002/9781118228920
- 2. Schramm LL, Stasiuk EN, Marangoni DG. Surfactants and their applications. Annual Reports Section “C” (Physical Chemistry) 2003; 99: 3-48. doi: 10.1039/B208499F
- 3. Ghosh S, Ray A, Pramanik N. Self-assembly of surfactants: An overview on general aspects of amphiphiles. Biophysical Chemistry 2020; 265: 106429. doi: 10.1016/j.bpc.2020.106429
- 4. Pandey V, Kohli S. Lipids and Surfactants: The inside story of lipid-based drug delivery systems. Critical Reviews in Therapeutic Drug Carrier Systems 2018; 35 (2): 99-155. doi: 10.1615/CritRevTherDrugCarrierSyst.2018016710
- 5. Gerola AP, Costa PFA, Quina FH, Fiedler HD, Nome F. Zwitterionic surfactants in ion binding and catalysis. Current Opinion in Colloid & Interface Science 2017; 32: 39-47. doi: 10.1016/j.cocis.2017.10.002
- 6. Chaudhari SP, Dugar RP. Application of surfactants in solid dispersion technology for improving solubility of poorly water soluble drugs. Journal of Drug Delivery Science and Technology 2017; 41: 68-77. doi: 10.1016/j.jddst.2017.06.010
- 7. Mir M, Ahmed N, Rehman AU. Recent applications of PLGA based nanostructures in drug delivery. Colloids and Surfaces B: Biointerfaces 2017; 159: 217-31. doi: 10.1016/j.colsurfb.2017.07.038
- 8. Nanaki S, Siafaka P, Zachariadou D, Nerantzaki M, Giliopoulos DJ et al. PLGA/SBA 15 mesoporous silica composite microparticles loaded with paclitaxel for local chemotherapy. European Journal of Pharmaceutical Sciences 2017; 99: 3R 44.
- 9. Spiridoula K, George M, Sofia P, Evangelos K, Dimitrios B et al. PPSu-PEG Copolymers and their Application in the Preparation of Cisplatin-loaded Nanoparticles. Current Nanoscience 2011; 7 (4): 503-09. doi: 10.2174/157341311796196880
- 10. Tsolou A, Angelou E, Didaskalou S, Bikiaris D, Avgoustakis K et al. Folate and pegylated aliphatic polyester nanoparticles for targeted anticancer drug delivery. International Journal of Nanomedicine 2020; 15: 4899-918. doi: 10.2147/IJN.S244712
- 11. Barichello JM, Morishita M, Takayama K, Nagai T. Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method. Drug Development and Industrial Pharmacy 1999; 25 (4): 471-76. doi: 10.1081/DDC-100102197
- 12. Martínez Rivas CJ, Tarhini M, Badri W, Miladi K et al. Nanoprecipitation process: From encapsulation to drug delivery. International Journal of Pharmaceutics 2017; 532 (1): 66-81. doi: 10.1016/j.ijpharm.2017.08.064
- 13. Heinz H, Pramanik C, Heinz O, Ding YF, Mishra RK et al. Nanoparticle decoration with surfactants: Molecular intercations, assmbly, and applications. Surface Science Reports 2017; 72 (1): 1-58. doi: 10.1016/j.surfrep.2017.02.001
- 14. Swider E, Koshkina O, Tel J, Cruz LJ, de Vries IJM et al. Customizing poly(lactic-co-glycolic acid) particles for biomedical applications. Acta Biomaterialia 2018; 73: 38-51. doi: 10.1016/j.actbio.2018.04.006
- 15. Shkodra-Pula B, Grune C, Traeger A, Vollrath A, Schubert S et al. Effect of surfactant on the size and stability of PLGA nanoparticles encapsulating a protein kinase C inhibitor. International Journal of Pharmaceutics 2019; 566: 756-64. doi: 10.1016/j.ijpharm.2019.05.072
- 16. Khatua A, Prasad A, Priyadarshini E, Virmani I, Ghosh l et al. CTAB-PLGA curcumin nanoparticles: preparation, biophysical characterization and their enhanced antifungal activity against phytopathogenic fungus pythium ultimum. Chemistry Select 2020; 5 (34): 10574-80. doi: 10.1002/slct.202002158
- 17. Sanna V, Roggio AM, Siliani S, Piccinini M, Marceddu S et al. Development of novel cationic chitosan-and anionic alginate-coated poly(D,Llactide-co-glycolide) nanoparticles for controlled release and light protection of resveratrol. International journal of nanomedicine 2012; 7: 5501-16. doi: 10.2147/IJN.S36684
- 18. Zhou J, Romero G, Rojas E, Ma L, Moya S et al. Layer by layer chitosan/alginate coatings on poly(lactide-co-glycolide) nanoparticles for antifouling protection and Folic acid binding to achieve selective cell targeting. Journal of Colloid and Interface Science 2010; 345 (2): 241-47. doi: 10.1016/j.jcis.2010.02.004
- 19. Anilanmert B, Yalçin G, Ariöz F, Dölen E. The spectrophotometric determination of cisplatin in urine, using o-phenylenediamine as derivatizing agent. Analytical Letters 2001; 34 (1): 113-23. doi: 10.1081/AL-100002709
- 20. Dinarvand R, Sepehri N, Manoochehri S, Rouhani H, Atyabi F. Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents. International Journal of Nanomedicine 2011; 6: 877-95. doi: 10.2147/IJN.S18905
- 21. Domínguez-Ríos R, Sánchez-Ramírez DR, Ruiz-Saray K, Oceguera-Basurto PE, Almada M et al. Cisplatin-loaded PLGA nanoparticles for HER2 targeted ovarian cancer therapy. Colloids and Surfaces B: Biointerfaces 2019; 178: 199-207. doi: 10.1016/j.colsurfb.2019.03.011
- 22. Cheng L, Jin C, Lv W, Ding Q, Han X. Developing a highly stable PLGA-mPEG nanoparticle loaded with cisplatin for chemotherapy of ovarian cancer. PLoS One 2011; 6 (9): e25433. doi: 10.1371/journal.pone.0025433
- 23. Gryparis EC, Mattheolabakis G, Bikiaris D, Avgoustakis K. Effect of conditions of preparation on the size and encapsulation properties of PLGA-mPEG nanoparticles of cisplatin. Drug Delivery 2007; 14 (6): 371-80. doi: 10.1080/10717540701202937