Peruze AYHAN EŞİYOK, Özlem SEVEN, Gülüzar EYMUR, Gamze BORA TATAR, Didem DAYANGAÇ ERDEN, Kemal YELEKÇİ, Hayat YURTER, Ayhan Sıtkı DEMİR

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

New aryl butenoic acid derivatives have been synthesized by combining hydroxy- or methoxy-substituted phenyl rings as the capping group, with a double bond in the short linker as well as metal binding groups, enoic ester, and salts bearing either methyl or morpholine. These compounds have been shown to possess promising histone deacetylase inhibition activities via in vitro fluorometric assay and molecular docking studies.

Anahtar Kelimeler:

Histone deacetylase inhibition activity, aryl butenoic acid derivatives, molecular docking

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Keywords:

Histone deacetylase inhibition activity, aryl butenoic acid derivatives, molecular docking,

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