Fazel NASUHI PUR, Karim AKBARI DILMAGHANI

Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Four 6-aminopenicillanic acid moieties were grafted at either rim of calix[4]arene, giving 2 novel generations of penicillin, which were named calixpenam. Antibiotic tests showed that they have amplified activity with respect to the corresponding penams against 3 gram-positive nonpenicillinase-producing strains of Streptococcus.

Anahtar Kelimeler:

Calixpenam, Calixarene, 6-aminopenicillanic acid, nonpenicillinase, Streptococcus strains

Calixpenams: synthesis, characterization, and biological evaluation of penicillins V and X clustered by calixarene scaffold

Keywords:

Calixpenam, Calixarene, 6-aminopenicillanic acid, nonpenicillinase, Streptococcus strains,

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