Pınar KARA, Kağan DAĞDEVİREN, Mehmet ÖZSÖZ

An Electrochemical DNA Biosensor for the Detection of DNA Damage Caused by Radioactive Iodine and Technetium

A DNA damage process by radioactive iodine (I-131) and technetium (Tc-99m) is described. The procedure relies on a label-free electrochemical DNA biosensor. Fish sperm double stranded DNA was immobilized onto a carbon paste electrode (CPE) by electro deposition and the changes to the guanine oxidation signal were observed upon exposure to radioactive I-131 and Tc-99m by differential pulse voltammetry (DPV). The changes to the signal of guanine after exposure to therapeutic doses of Tc-99m and I-131 showed conformational changes in DNA molecules.

Anahtar Kelimeler:

Electrochemistry, DNA damage, Tc-99m, iodine-131

An Electrochemical DNA Biosensor for the Detection of DNA Damage Caused by Radioactive Iodine and Technetium

Keywords:

Electrochemistry, DNA damage, Tc-99m, iodine-131,

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