A near-infrared ﬂuorescent sensor for $H^ +$ in aqueous solution and living cells

A heptamethine cyanine-based sensor (1) was designed and synthesized by incorporating heptamethine cyanine ﬂuorophore and methylpiperazine. Sensor 1 exhibited good response to the change of pH levels, and a large Stokes shift (>100 nm) was obtained. Fluorescent image experiments in living cells further demonstrated its potential applications in biological systems.

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