Shadia Mahmoud ABDALLAH, Halima Aly HEFNY

3514

Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones

Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of a,b-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.
Anahtar Kelimeler:

Microwave, butenamides, pyrrolidines, sulfonamides, biological activity, antiproliferative activity

Microwave synthesis of some new antimicrobial and antiproliferative butenamides and pyrrolidine-2,5-diones

Microwave irradiation, comparable to conventional thermal heating, proves to be a convenient method in assisting the synthesis of some butenamides, pyrrolidine-2,5-diones, and their benzenesulfonamido derivatives, which are known to have biological activities and wide medical and industrial applications. Both procedures were used to compare their efficiency in synthesizing butenamides and pyrrolidine-2,5-diones (2-25), which have important and wide applications, from condensation of a,b-unsaturated anhydride (1) with the corresponding amines. Some of the products showed biological or cytotoxic (antiproliferative) activity.
Keywords:

Microwave, butenamides, pyrrolidines, sulfonamides, biological activity, antiproliferative activity,

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Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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