___

• ReferencesAebi H (1974). Catalase. In: Bergmeyer HU, editor. Methods of Enzymatic Analysis. New York, NY, USA: Academic Press, pp. 673–684.Ahsan H, Reagan-Shaw S, Breur J, Ahmad N (2007). Sanguinarine induces apoptosis of human pancreatic carcinoma AsPC-1 and BxPC-3 cells via modulations in Bcl-2 family proteins. Cancer Lett 249: 198–208. Arya R, Mallik M, Lakhotia SC (2007). Heat shock genes—integrating cell survival and death. J Biosci 32: 595–610.Beutler E (1984). Glutathione peroxidase. In: Beutler E, editor. Red Cell Metabolism. A Manual of Biochemical Methods. Orlando, FL, USA: Grune & Stratlon, pp. 74–76.Burgeiro A, Bento AC, Gajate C, Oliveira PJ, Mollinedo F (2013). Rapid human melanoma cell death induced by sanguinarine through oxidative stress. Eur J Pharmacol 705: 109–118.Chandra D, Choy G, Tang DG (2007). Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J Biol Chem 282: 31289–31301.Choi YH, Choi WY, Hong SH, Kim SO, Kim GY, Lee WH, Yoo YH (2009). Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact 179: 185–191. Conforti F, Menichini F, Rigano D, Senatore F (2009). Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumilaflowers and rhizomes. Z Naturforsch C 64: 490–494. De Stefano I, Raspaglio G, Zannoni GF, Travaglia D, Prisco MG, Mosca M, Ferlini C, Scambia G, Gallo D (2009). Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma. Biochem Pharmacol 78: 1374–1381.Dinischiotu A, Stanca L, Gradinaru D, Petrache SN, Radu M, Serban AI (2013). Lipid peroxidation due to in vitro and in vivo exposure of biological samples to nanoparticles. Methods Mol Biol 1028: 155–164. Ekoue DN, Diamond AM (2014). It takes 2 antioxidants to tango: the interaction between manganese superoxide dismutase and glutathione peroxidase-1. Turk J Biol 38: 748–753.Faddeeva MD, Beliaeva TN (1997). Sanguinarine and ellipticine cytotoxic alkaloids isolated from well-known antitumor plants. Intracellular targets of their action. Tsitologiia 39: 181–208.Feng X, Bonni S, Riabowol K (2006). Hsp 70 Induction by ING proteins sensitizes cells to tumor necrosis factor alpha receptor-mediated apoptosis. Mol Cel Biol 26: 9244–9255.Ganea E, Harding JJ (2000). α-Crystallin protects glucose-6-phosphate dehydrogenase against inactivation by malondialdehyde. Biochem Biophys Acta 1500: 49–58.Gao Y, Han C, Huang H, Xin Y, Xu Y, Luo L, Yin Z (2010). Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-alpha induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1. Apoptosis 15: 822–833. Ghosh JC, Dohi T, Kang BH, Altieri DC (2008). Hsp60 regulation of tumor cell apoptosis. J Biol Chem 283: 5188–5194. Goldberg DM, Spooner RJ (1983). Glutathione reductase. In: Bergmeyer HU, editor. Methods of Enzymatic Analysis. Weinheim, Germany: Verlag Chemie, pp. 258–265.Gupta S, Knowlton AA (2002). Cytosolic heat shock protein 60 hypoxia and apoptosis. Circulation 106: 2727–2733. Habig WH, Pabst MJ, Jakobz WB (1974). Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130–7139.Hammerová J, Uldrijan S, Táborská E, Slaninová I (2011). Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci 62: 22–35.Han MH, Kim GY, Yoo YH, Choi YH (2013). Sanguinarine induces apoptosis in human colorectal cancer HCT-116 cells through ROS-mediated Egr-1 activation and mitochondrial dysfunction. Toxicol Lett 220: 157–166.Huh J, Liepins A, Zielonka J, Andrekopoulos C, Kalyanaraman B, Sorokin A (2006). Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. Cancer Res 66: 3726–3736. Joshi PV, Lele VR, Aland NJ, Bhat G, Ajunkya SP, Patel RP (2012). Malignant amelanotic melanoma—a diagnostic surprise: flurodeoxyglocose positron emission tomography-computed tomography and immunohistochemistry clinch the ‘final diagnosis’. J Can Res Ther 8: 451–453.Kemény-Beke A, Aradi J, Damjanovich J, Beck Z, Facskó A, Berta A, Bodnár A (2006). Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine. Cancer Lett 237: 67–75.Kim JY, Kim SM, Ko JH, Yim JH, Park JH, Park JH (2006). Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. FEBS Lett 580: 3270–3275.Lanneau D, Brunet M, Frisan E, Solary E, Fontenay M, Garrido C (2008). Heat shock proteins: essential proteins for apoptosis regulation. J Cell Mol Med 12: 743–761.Lee JS, Jung WK, Jeong MH, Yoon TR, Kim HK (2012). Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway. Internat J Toxicol 31: 70–77.Lohr GW, Waller HD (1974). Glucose-6-phosphate dehydrogenase. In: Bergmeyer HV, editor. Methods of Enzymatic Analysis. New York, NY, USA: Academic Press, pp. 636–646.Loizzo MR, Tundis R, Menichini F, Saab AM, Statti GA, Menichini F (2007). Cytotoxic activity of essential oils from labiatae and lauraceae families against in vitro human tumor models. Anticancer Res 27: 3293–3299.Maheswaran S, Englert C, Zheng G, Lee SB, Wong J, Harkin DP, Bean J, Ezzell R, Garvin AJ, McCluskey RT et al. (1998). Inhibition of cellular proliferation by the Wilms tumor suppressor WT/requires association with the inducible chaperone Hsp70. Genes Dev 12: 1108–1120.Matkar SS, Wrischnik LA, Hellmann-Blumberg U (2008). Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis. Arch Biochem Biophys 477: 43–52.Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55–63.Nadova S, Miadokova E, Alfoldiova L, Kopaskova M, Hasplova K, Hudecova A, Vaculcikova D, Gregan F, Cipak L (2008). Potential antioxidant activity, cytotoxic and apoptosis-inducing effects of Chelidonium majus L. extract on leukemia cells. Neuro Endocrinol Lett 29: 649–652.Ökten S, Erenler R, Kul Köprülü T, Tekin Ş (2015). In vitro antiproliferative/cytotoxic activity of 2,3ʹ-biindole against various cancer cell lines. Turk J Biol 39: 15–22.Paoletti F, Mocali A (1990). Determination of superoxide dismutase activity by purely chemical system based on NADP(H) oxidation. Methods Enzymol 186: 209–221.Philchenkov A, Kaminskyy V, Zavelevich M, Stoika R (2008). Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects. Toxicol In Vitro 22: 287–295.Photiou A, Sheikh MN, Bafaloukos D, Retsas S (1992). Antiproliferative activity of vinorelbine (Navelbine) against six human melanoma cell lines. J Cancer Res Clin Oncol 118: 249–254.Raisova M, Hossini AM, Eberle J, Riebeling C, Wieder T, Sturm I, Daniel PT, Orfanos CE, Geilen CC (2001). The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. J Invest Dermatol 117: 333–340.Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger JM, Garrido C et al. (2001). Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 3: 839–843.Serafim TL, Matos JA, Sardão VA, Pereira GC, Branco AF, Pereira SL, Parke D, Perkins EL, Moreno AJ, Holy J et al. (2008). Sanguinarine cytotoxicity on mouse melanoma K1735-M2 cells—nuclear vs. mitochondrial effects. Biochem Pharmacol 76: 1459–1475.Siwak DR, Shishodia S, Aggarwal BB, Kurzrock R (2005). Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104: 879–890.Townsend DM, Tew KD (2003). The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22: 7369–7375.Vejselova D, Kutlu HM (2015). Inhibitory effects of salicylic acid on A549 human lung adenocarcinoma cell viability. Turk J Biol 39: 1–5.Weerasinghe P, Hallock S, Liepins A (2001). Bax, Bcl-2 and NF-kappaB expression in sanguinarine induced bimodal cell death. Exp Mol Pathol 71: 89–98.Zhang F, Du G (2012). Dysregulated lipid metabolism in cancer. World J Biol Chem 3: 167–74.