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• ReferencesAkutsu M, Ye Y, Virdee S, Chin JW, Komander D (2011). Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains. P Natl Acad Sci 108: 2228–2233.Arguello MD, Hiscott J (2007). Ub surprised: viral ovarian tumor domain proteases remove ubiquitin and ISG15 conjugates. Cell Host Microbe 2: 367–369.Bakshi S, Holzer B, Bridgen A, McMullan G, Quinn DG, Baron MD (2013). Dugbe virus ovarian tumour domain interferes with ubiquitin/ISG15-regulated innate immune cell signalling. J Gen Virol 94: 298–307.Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M (2013). Crimean–Congo hemorrhagic fever: history epidemiology pathogenesis clinical syndrome and genetic diversity. Antiviral Res 100: 159–189.Bergeron E, Albariño CG, Khristova ML, Nichol ST (2010). Crimean–Congo hemorrhagic fever virus-encoded ovarian tumor protease activity is dispensable for virus RNA polymerase function. J Virol 84: 216–226.Capodagli GC, Deaton MK, Baker EA, Lumpkin RJ, Pegan SD (2013). Diversity of ubiquitin and ISG15 specificity among nairoviruses’ viral ovarian tumor domain proteases. J Virol 87: 3815–3827.Capodagli GC, McKercher MA, Baker EA, Masters EM, Brunzelle JS, Pegan SD (2011). Structural analysis of a viral ovarian tumor domain protease from the Crimean–Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. J Virol 85: 3621–3630.Chang MW, Ayeni C, Breuer S, Torbett BE (2010). Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina. PLoS ONE 5: e11955.Dokuzoguz B, Celikbas AK, Gök SE, Baykam N, Eroglu MN, Ergonul O (2013). Severity scoring index for Crimean–Congo hemorrhagic fever and the impact of ribavirin and corticosteroids on fatality. Clin Infect Dis 57: 1270–1274.Ergonul O (2012). Crimean–Congo hemorrhagic fever virus: new outbreaks new discoveries. Curr Opin Virol 2: 215–220.Ergunay K, Whitehouse CA, Ozkul A (2011). Current status of human arboviral diseases in Turkey. Vector Borne Zoonotic Dis 11: 731–741.Frias-Staheli N, Giannakopoulos NV, Kikkert M, Taylor SL, Bridgen A, Paragas J, Richt JA, Rowland RR, Schmaljohn CS, Lenschow DJ et al. (2007). Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses. Cell Host Microbe 2: 406–416.Gale P, Stephenson B, Brouwer A, Martinez M, la Torre de A, Bosch J, Foley-Fisher M, Bonilauri P, Lindström A, Ulrich RG et al. (2012). Impact of climate change on risk of incursion of Crimean–Congo haemorrhagic fever virus in livestock in Europe through migratory birds. J Appl Microbiol 112: 246–257.Gargili A, Midilli K, Ergonul O, Ergin S, Alp HG, Vatansever Z, Iyisan S, Cerit C, Yilmaz G, Altas K et al. (2011). Crimean–Congo hemorrhagic fever in European part of Turkey: genetic analysis of the virus strains from ticks and a seroepidemiological study in humans. Vector Borne Zoonotic Dis 11: 747–752.Han L, Wang Y, Bryant SH (2008). Developing and validating predictive decision tree models from mining chemical structural fingerprints and high–throughput screening data in PubChem. BMC Bioinformatics 9: 401. James TW, Frias-Staheli N, Bacik JP, Levingston Macleod JM, Khajehpour M, García-Sastre A, Mark BL (2011). Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease. P Natl Acad Sci 108: 2222–2227.Lindeborg M, Barboutis C, Ehrenborg C, Fransson T, Jaenson TG, T, Lindgren PE, Lundkvist A, Nyström F, Salaneck E, Waldenström J et al. (2012). Migratory birds, ticks, and Crimean–Congo hemorrhagic fever virus. Emerg Infect Dis 18: 2095–2097.Makarova KS, Aravind L, Koonin EV (2000). A novel superfamily of predicted cysteine proteases from eukaryotes viruses and Chlamydia pneumoniae. Trends Biochem Sci 25: 50–52.Malakhova OA, Zhang DE (2008). ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response. J Biol Chem 283: 8783–8787.Nanao MH, Tcherniuk SO, Chroboczek J, Dideberg O, Dessen A, Balakirev MY (2004). Crystal structure of human otubain 2. EMBO Rep 5: 783–788.Ozkaya E, Dincer E, Carhan A, Uyar Y, Ertek M, Whitehouse CA, Ozkul A (2010). Molecular epidemiology of Crimean–Congo hemorrhagic fever virus in Turkey: occurrence of local topotype. Virus Res 149: 64–70.Palomar AM, Portillo A, Santibáñez P, Mazuelas D, Arizaga J, Crespo A, Gutiérrez Ó, Cuadrado JF, Oteo JA (2013). Crimean–Congo hemorrhagic fever virus in ticks from migratory birds, Morocco. Emerg Infect Dis 19: 260–263.Sanner MF (1999). Python: a programming language for software integration and development. J Mol Graph Model 17: 57–61.Sanner MF, Olson AJ, Spehner JC (1996). Reduced surface: an efficient way to compute molecular surfaces. Biopolymers 38: 305–320.Snijder EJ, Wassenaar AL, Spaan WJ (1994). Proteolytic processing of the replicase ORF1a protein of equine arteritis virus. J Virol 68: 5755–5764.Snijder EJ, Wassenaar AL, Spaan WJ, Gorbalenya AE (1995). The arterivirus Nsp2 protease, an unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases. J Biol Chem 270: 16671–16676.Sudha KN, Shakira M, Prasanthi P, Sarika N, Kumar CN, Babu PA (2008). Virtual screening for novel COX-2 inhibitors using the ZINC database. Bioinformation 2: 325–329.Trott O, Olson AJ (2009). AutoDock Vina: improving the speed and accuracy of docking with a new scoring function efficient optimization and multithreading. J Comput Chem 31: 455–461.van Kasteren PB, Beugeling C, Ninaber DK (2012). Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling. J Virol 86: 773–785.Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, Zhou Z, Han L, Karapetyan K, Dracheva S, Shoemaker BA et al. (2011). PubChem’s BioAssay database. Nucleic Acids Res 40: D400–D412.Wassman CD, Baronio R, Demir OZ, Wallentine BD, Chen CK, Hall LV, Salehi F, Lin DW, Chung BP, Hatfield GW et al. (2013). Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53. Nat Commun 4: 1407.Weber F, Mirazimi A (2008). Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis. Cytokine Growth Factor Rev 19: 395–404.Whitehouse CA (2004). Crimean–Congo hemorrhagic fever. Antiviral Res 64: 145–160.Yang JM, Chen YF, Tu YY, Yen KR, Yang YL (2007). Combinatorial computational approaches to identify tetracycline derivatives as flavivirus inhibitors. PLoS ONE 2: e428.