___

• Adhami M, Ghori Javed FY, Chen H, Gutierrez SE, Javed A (2011). Runx2 regulates the gene network associated with insulin signaling and energy homeostasis. Cell Tissue Organ 194: 232–237.
• Aiken A, Khokha R (2010). Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice. Biochim Biophys Acta 1803: 121–132.
• Akyol S, Acar M, Ünal ZN, Hasgül R, Erdoğan S, Demircan K, Akyol Ö, Yiğitoğlu MR (2013). The effects of caffeic acid phenethyl ester (CAPE), royal jelly, and curcumin on gene expression of ADAMTS1, 5 and 9 in OUMS-27 chondrosarcoma cells: a preliminary study. Ann Pediatr Rheumatol 2: 27–37.
• Akyol S, Cömeroğlu İ, Firat R, Çakmak Ö, Yukselten Y, Erden G, Ugurcu V, Demircan K (2015a). Effect of insulin on the mRNA expression of procollagen N-proteinases in chondrosarcoma OUMS-27 cells. Oncol Lett 10: 1091–1096.
• Akyol S, Erdemli HK, Kurşunlu SF, Aynekin B, Yaral Y, Yiğitoğlu MR, Demircan K (2015b). ADAMTS family in matricellular remodeling: a biochemical glance. Yeni Tıp Dergisi 32: 67–74 (article in Turkish with an abstract in English).
• Akyol S, Ugurcu V, Cakmak O, Altuntas A, Yukselten Y, Akyol O, Sunguroglu A, Demircan K (2014a). Evidence for the control of aggrecanases by insulin and glucose in Alzheimer’s disease. Bull Clin Psychopharmacol 24: 323–332.
• Akyol S, Yükselten Y, Çakmak Ö, Uğurcu V, Altuntaş A, Gürler M, Akyol Ö, Demircan K (2014b). Hydrogen peroxide induced oxidative damage in human chondrocytes: the prophylactic effects of Hypericum perforatum Linn extract on deoxyribonucleic acid damage, apoptosis and matrix remodeling by a disintegrin-like and metalloproteinase with thrombospondin motifs proteinases. Arch Rheumatol 29: 203–214.
• Altuntaş A, Akyol S, Adam B, Çakmak Ö, Uğurcu V, Erden G, Yükselten Y, Demircan K (2015). ADAMTS12 depletion by insulin in OUMS-27 human chondrosarcoma cells. Arch Rheumatol 30: 96–103.
• Arner EC (2002). Aggrecanase-mediated cartilage degradation. Curr Opin Pharmacol 2: 322–329.
• Beam HA, Parsons JR, Lin SS (2002). The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthop Res 20: 1210–1216.
• Bizzarri C, Benevento D, Giannone G, Bongiovanni M, Anziano M, Patera IP, Cappa M, Cianfarani S (2014). Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus. Growth Horm IGF Res 24: 256–9.
• Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN (2014). Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep 14: 552–562.
• Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O’Keefe RJ, Xing L, Mooney RA, Zuscik MJ (2014). Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. PLoS One 9: e99656.
• Cawston TE, Wilson AJ (2006). Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. Best Pract Res Clin Rheumatol 20: 983–1002.
• Chaudhary SB, Liporace FA, Gandhi A, Donley BG, Pinzur MS, Lin SS (2008). Complications of ankle fracture in patients with diabetes. J Am Acad Orthop Surg 16: 159–170.
• Chiarelli F, Giannini C, Mohn A (2004). Growth, growth factors and diabetes. Eur J Endocrinol 151: U109–117.
• Demircan K, Cömertoğlu İ, Akyol S, Yiğitoğlu BN, Sarıkaya E (2014). A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS). J Turk Ger Gynecol Assoc 15: 250–255.
• Demircan K, Akyol S, Armutcu F (2013). A multi-functional gene family from arthritis to cancer: a disintegrin-like metalloproteinase with thrombospondin type-1 motif (ADAMTS). J Clin Anal Med 4: 429–434 (article in Turkish with an abstract in English).
• Demircan K, Hirohata S, Nishida K, Hatipoglu OF, Oohashi T, Yonezawa T, Apte SS, Ninomiya Y (2005). ADAMTS-9 is synergistically induced by interleukin-1 beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes. Arthritis Rheum 52: 1451–1460.
• Fennoy I (2013). Effect of obesity on linear growth Curr Opin Endocrinol Diabetes Obes 20: 44–49.
• Firat R, Akyol S, Kursunlu F, Ugurcu V, Erden G, Cakmak O, Demircan K (2014). ADAMTS13 expression in human chondrosarcoma cells induced by insulin. J Clin Exp Invest 5: 226–232.
• Foley TP, Nissley SP, Stevens RL, King GL, Hascall VC, Humbel RE, Short PA, Rechler MM (1982). Demonstration of receptors for insulin and insulin-like growth factors on swarm rat chondrosarcoma chondrocytes. J Biol Chem 257: 663–669.
• Follak N, Kloting L, Wolf E, Merk H (2004). Delayed remodeling in the early period of fracture healing in spontaneously diabetic BB/OK rats depending on the diabetic metabolic state. Histol Histopathol 19: 473–486.
• Gandhi A, Beam HA, O’Connor JP, Parsons JR, Lin SS (2005). The effects of local insulin delivery on diabetic fracture healing. Bone 37: 482–490.
• Gerstenfeld LC, Wronski TJ, Hollinger JO, Einhorn TA (2005). Application of histomorphometric methods to the study of bone repair. J Bone Miner Res 20: 1715–1722.
• Giannini C, Mohn A, Francesco Chiarelli (2014). Growth abnormalities in children with type 1 diabetes, juvenile chronic arthritis, and asthma. Int J Endocrinol 2014: 1–10. Article ID 265954.
• Glade MJ, Kanwar YS, Stern PH (1994). Insulin and thyroid hormones stimulate matrix metabolism in primary cultures of articular chondrocytes from young rabbits independently and in combination. Connect Tissue Res 31: 37–44.
• Hamann C, Goettsch C, Mettelsiefen J, Henkenjohann V, Rauner M, Hempel U, Bernhardt R, Fratzl-Zelman N, Roschger P, Rammelt S et al. (2011). Delayed bone regeneration and low bone mass in a rat model of insulin-resistant type 2 diabetes mellitus is due to impaired osteoblast function. Am J Physiol Endocrinol Metab 301: E1220–E1228.
• Hardingham TE, Fosang AJ (1992). Proteoglycans: many forms and many functions. FASEB J 6: 861–870.
• Hatipoglu OF, Hirohata S, Cilek MZ, Ogawa H, Miyoshi T, Obika M, Demircan K, Shinohata R, Kusachi S, Ninomiya Y (2009). ADAMTS1 is a unique hypoxic early response gene expressed by endothelial cells. J Biol Chem 284: 16325–16333.
• Hidaka K, Kanematsu T, Takeuchi H, Nakata M, Kikkawa U, Hirata M (2001). Involvement of the phosphoinositide 3-kinase/ protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5. Int J Biochem Cell Biol 33: 1094–1103.
• Hou CJ, Liu JL, Li X, Bi LJ (2012). Insulin promotes bone formation in augmented maxillary sinus in diabetic rabbits. Int J Oral Maxillofac Surg 41: 400–407.
• Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, Krane SM (2004). Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci USA 101: 17192–17197.
• Jiao H, Xiao E, Graves DT (2015). Diabetes and its effect on bone fracture healing. Curr Osteoporos Rep 13: 327–335.
• Kayal RA, Alblowi J, McKenzie E, Krothapalli N, Silman L, Gerstenfeld L, Einhorn TA, Graves DT (2009). Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone 44: 357–363.
• Kumagishi K, Nishida K, Yamaai T, Momota R, Miyaki S, Hirohata S, Naito I, Asahara H, Ninomiya Y, Ohtsuka A (2009). A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification. Arch Histol Cytol 72: 175–185.
• Kuno K, Kanada N, Nakashima E, Fujiki F, Ichimura F, Matsushima K (1997). Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J Biol Chem 272: 556–562.
• Little CB, Mittaz L, Belluoccio D, Rogerson FM, Campbell IK, Meeker CT, Bateman JF, Pritchard MA, Fosang AJ (2005). ADAMTS 1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis Rheum 52: 1461–1472.
• Lu H, Kraut D, Gerstenfeld, LC, Graves DT (2003). Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation. Endocrinology 144: 346–352.
• Malfait AM, Liu RQ, Ijiri K, Komiya S, Tortorella MD (2002). Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem 277: 22201–22208.
• Mandal M, Mandal A, Das S, Chakraborti T, Sajal C (2003). Clinical implications of matrix metalloproteinases. Mol Cell Biochem 252: 305–329.
• Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O’Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E (2014). Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol 393: 124–136.
• Maor G, Karnieli E (1999). The insulin-sensitive glucose transporter (GLUT4) is involved in early bone growth in control and diabetic mice, but is regulated through the insulin-like growth factor I receptor. Endocrinology 140: 1841–1851.
• Martin JA, Scherb MB, Lembke LA, Buckwalter MD (2000). Damage control mechanisms in articular cartilage. Iowa Orthop J 20: 1–10.
• Nevins ML, Karimbux NY, Weber HP, Giannobile WV, Fiorellini JP (1998). Wound healing around endosseous implants in experimental diabetes. Int J Oral Maxillofac Implants 13: 620– 629.
• Olza J, Aguilera CM, Gil-Campos M, Leis R, Bueno G, Valle M, Canete R, Tojo R, Moreno LA, Gil A (2014). Waist-to-height ratio, inflammation and CVD risk in obese children. Public Health Nutr 2: 1–8.
• Otsu K, Geary ES, Stevens RL (1988). Aberrant regulation of the metabolism of the insulin receptor in Swarm rat chondrosarcoma chondrocytes. Biochem J 254: 203–209.
• Phornphutkul C, Wu KY, Gruppuso PA (2006). The role of insulin in chondrogenesis. Mol Cell Endocrinol 249: 107–115.
• Rogerson FM, Stanton H, East CJ, Golub SB, Tutolo L, Farmer PJ, Fosang AJ (2008). Evidence of a novel aggrecan-degrading activity in cartilage: studies of mice deficient in both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 58: 1664–1673.
• Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, Rodriguez-Mazaneque JC, Zimmermann DR, Lemire JM, Fischer JW, Wight TN et al. (2001). Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J Biol Chem 276: 13372–13378.
• Shaibi GQ, Cruz ML, Ball GD, Weigensberg MJ, Salem GJ, Crespo NC, Goran MI (2006). Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc 38: 1208–1215.
• Shukunami C, Ishizeki K, Atsumi T, Ohta Y, Suzuki F, Hiraki Y (1997). Cellular hypertrophy and calcification of embryonal carcinoma-derived chondrogenic cell line ATDC5 in vitro. J Bone Miner Res 12: 1174–1188.
• Sparks JD, O’Dell C, Chamberlain JM, Sparks CE (2013). Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases. Biochem Biophys Res Commun 435: 616–620.
• Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK et al. (2005). ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434: 648–652.
• Stovitz SD, Hannan PJ, Lytle LA, Demerath EW, Pereira MA, Himes JH (2010). Child height and the risk of young-adult obesity. Am J Prev Med 38: 74–77.
• Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R et al. (1999). Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 284: 1664–1666.
• Twining SS (1994). Regulation of proteolytic activity in tissues. Crit Rev Biochem Mol Biol 29: 315–383.
• Uğurcu V, Akyol S, Altuntaş A, Fırat R, Kurşunlu SF, Çakmak Ö, Demircan K (2014). The effects of insulin on the expression levels of ADAMTS6 & 19 in OUMS-27 cell. Dicle Med J 41: 451–456.
• Uysal S, Ünal ZN, Erdoğan S, Akyol S, Yiğitoğlu MR, Hirohata S, Işık B, Demircan K (2013). Augmentation of ADAMTS9 gene expression by IL-1 beta is reversed by NF kappa B and MAPK inhibitors, but not PI3 kinase inhibitors. Cell Biochem Funct 31: 539–544.
• White CB, Turner NS, Lee GC, Haidukewych GJ (2003). Open ankle fractures in patients with diabetes mellitus. Clin Orthop Relat Res 414: 37–44.
• Yamanishi Y, Boyle DL, Clark M, Maki RA, Tortorella MD, Arner EC, Firestein GS (2002). Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. J Immunol 168: 1405–1412.
• Yaykasli KO, Oohashi T, Hirohata S, Hatipoglu OF, Inagawa K, Demircan K, Ninomiya Y (2009). ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. Mol Cell Biochem 323: 69– 79