Pestisidlerin kronik etkisine maruz kalan tarım işçilerinde karaciğer fonksiyonlarının incelenmesi

İçel ili ve çevresi tarım alanlarında çalışan ve pestisidlerin kronik etkisine maruz kalan tarım işçilerinden kan örnekleri alınmış ve serum AST,ALT, ALP, LDH, total protein, albümin ve globülin değerleri ölçülmüştür (n=150). Aynı ölçümler pestisidlere doğrudan maruz kalmayan 64 kişide de yapılmıştır. Tarım işçilerinde AST, ALT, ALP ve LDH değerlerinde kontrol grubuna göre anlamlı bir artış gözlenirken (p

Investigation of the liver functions in agricultural workers chronically exposed to pesticides

Blood samples were taken from agricultural workers who had been exposed to pesticides for long periods in Içel and the surrounding agricultural areas (n=150) and levels of AST, ALT, ALP, LDH, total protein, albumin and globulin in serum were determined. The same parameters were measured in 64 persons who are not exposed to pesticides in any way. Study group showed significantly higher levels of AST, ALT, ALP and LDH (p

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  • 1. McEven, F.L., Stephenson, G.L., The use and significiance of pesticides in the environment. John Wiley & Sons Pub., New York 538, 1979.
  • 2. Amdur, M.O., Doull, J., Klassen, C.D., Casarett and Doull’s Toxicology. The basic science of poisons, Pergamon Press, New York 1033, 1991.
  • 3. Guest, J.A., Copley, M.P., Homernic, K.L., Carcinogenic effects of pesticides. Pathol Pharmacol., 71(3): 387-390, 1991
  • 4. Curley, F.D., Arch. Environm. Contam. Toxicol., 1977.
  • 5. Ami, B.H., Haim, S. A., Direct effect of phosphamidon on isolated working rat heart electrical and mechanical function. Toxicol., Apply Pharmacol., 110 (3) : 429-434, 1992.
  • 6. Izushi, F., Ogata, M., Hepatic and muscle injuries in mice treated with heptachlor Toxicol. Lett. 54 (1) 47-54 1990.
  • 7. Weizman, Z., Sofer, S., Acute pancreatitis in children with anticholinesterase insecticide intoxication. Pediatrics. 204-206 1992.
  • 8. Blasiak, J., Walter Z., Bawronska, M., The changes of osmotic fragility of pig organophosphorus insecticides. Acta Biochim. Pol. 38 (1) 75-80. 1991.
  • 9. Datta, C., Gupta, J., Sarkar, A., Sengupta, D., Effects of organophosphorus insecticide phosphomidon on antioxidant defence components of human erythrocyte and plasma. Indian J. Exp. Biol. 30 (1) 65- 67 1992.
  • 10. Pope, C.N., Charracborti, T.K., Dose-releated inhibition of brain and plasma cholinesterase in neonatal and adult rats following sublethal organophosphate exposures. Toxicology, 73. 35-42, 1992.
  • 11. Philip, G.H., Reddy, P.M., Sridevi, G., Cypermetrin-induced in vivo alterethions in the carbonhydrate metobolism of freshwater fish, Labeo rohita. Ecotoxicol Environ 31 (12) p 173-178, 1995.
  • 12. Izushi, F., Ogata M., Hepatic and muscle injuries in mice treated with heptaclor Toxicol Lett. 54 (1) p 47-54, 1990.
  • 13. Brovwer, E.J., Evelo, C.T., Verplanke, A.J., van Welie, R.T., de Wolf, F.A., Biological effect monitoring of occupational exposure to 1,3 dichloropropene : effects on liver and renal function and on glutathione conjugation. Br. J. ınd. Med.. 48 (3) p 167-172, 1991.
  • 14. Mayer, F.L., Versteeg, D.J., McKee, M.J., Physiological and Nonspecific Biomarkers; Biomarkers, Eds. Hugget et al., Lewis Pub. , 5-86, 1992.
  • 15. Blain, P.G. Aspect of pesticide toxicology. Adverse Drug React Acute Poisoning Rev. 9 (1) p37-68. 1990
  • 16. Moses, M., Pesticide-related health problems and farmworkers. AAOHN J. 37 (3) 115-130, 1989.
  • 17. Küçükyurt, Y., Aker, A.,Atalay, A., Dietilnitrosaminin farelerde serum ve karaciğer total protein, albümin değerleri ile asit ve alkali fosfataz aktivitelerine etkisi. C.Ü. Tıp Fak. Dergisi, 12 (2):207-220, 1990.
  • 18. Noyan, A: Yaşamda ve Hekimlikte Fizyoloji, Ankara, 1993 Meteksan Aş.
  • 19. Tortora, J.G., and Grabowski, S.R.: Principles of Anatomy and Physiology, 1996, Harper Collins College Publishers.
  • 20. Marshall, W.J., Bangert, S.K.: Clinical Biochemistry, New York, 1995, Churchıll Livingstone.
  • 21. Gözükara, E.M.: Biyokimya, Ankara, 1990, Repromat Ltd. şti., 710.
  • 22. Akın, G., Pekgöz, E., Gökhun, ı.H. Karaciğer. Tertip matbaası, 90, 1992.
  • 23. Kamal, AAM., Elgary, MT., Maklady, F., Mostafa, MA., Massaud, A., Serum cholinesterase and liver function among a group of organophosphorus pesticides sprayers in Egypt. J Toxicol. Cin. Experimentale, 10: 7-8, 427-435, 1990.
  • 24. Aras, K., Ersen, G., Klinik Biyokimya. Taş Kitapçılık Ltd. şti. 338, 1992.
  • 25. Karayılanoğlu, T., Demirci, D., Karayılanoğlu, V., Kronik alkoliklerde bazı biyokimyasal parametrelerin değerlendirilmesi. Biyokimya dergisi, XVı (3): 51-56, 1991.
  • 26. Çömelekoğlu, Ü., Arpacı, A., Mazmancı, B. Pestisidlerle kronik olarak karşılaşan tarım işçilerinin pestisidlerden korunma konusundaki tutumları, 3. İşçi Sağlığı kongresi, Ankara, 1998.