Genomic Imprinting: A Specialized Form of Gene Regulation
Genomic imprinting is a process resulting in the preferential expression of certain genes depending on whether the genetic material has been inherited from the mother or the father. Many imprinted genes have been identified as having important roles in mammalian development, and the loss of imprints as well as non-imprinted alleles causes a variety of developmental abnormalities and pathological conditions in both mice and humans. In this article, the phenomenon of genomic imprinting, the developmental implications of imprinting and the molecular mechanisms proposed for this process are reviewed.
Anahtar Kelimeler:
Genomic imprinting, Preferential gene expression, Gene regulation
Genomic Imprinting: A Specialized Form of Gene Regulation
Genomic imprinting is a process resulting in the preferential expression of certain genes depending on whether the genetic material has been inherited from the mother or the father. Many imprinted genes have been identified as having important roles in mammalian development, and the loss of imprints as well as non-imprinted alleles causes a variety of developmental abnormalities and pathological conditions in both mice and humans. In this article, the phenomenon of genomic imprinting, the developmental implications of imprinting and the molecular mechanisms proposed for this process are reviewed.
- ISSN: 1300-0152
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
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