Evaluation of the hypoglycemic and hypolipidemic activity of Butea monosperma fruit in diabetic human subjects

Normal ve diyabetik gönüllü insanlarda yerel Butea monosperma (Palas papra) meyvesinin hipoglisemik aktivitesinin değerlendirilmesi çalışılmıştır. Örnekleme Faisalabad şehri çevresindeki özellikle Khadija Mahmood Vakıf Hastanesi ve Pakistan, Faisalabad, Ziraat Üniversitesinde yapılmıştır. Gönüllüler, kan glukoz seviyelerine göre normal ve diyabetik denekler olarak kategorize edildi. 30 ve 60 yaş arası erkek ve kadın diyabetik gönüllüler çalışmaya katıldı. Tüm diyabetik gönüllüler tip II diyabetli yani insüline bağımlı olmayan diyabetliydi (NIDDM). Denekler 5 gruba ayrıldı. Grup A – Muamele görmemiş normal denekler; Grup B – B. monosperma meyvesini 30 gün boyunca toz halinde 30 mL su içinde 3 g olarak ağızdan alan normal denekler; Grup C – Kontrol diyabetik denekler; Grup D – 30 gün boyunca toz halinde 30 mL su içinde 3 g olarak ağızdan alan diyabetik denekler; Grup E – 30 gün boyunca 30 mL su içinde 5 mg Daonil® tablet (oral olarak alınan standart bir antidiyabetik ilaç) alan diyabetik denekler. 30 gün boyunca diyabetik ve normal denekler tarafından B. monosperma meyvesinin ağızdan alınımı, lipit profili ve karaciğer enzim aktivitesi kadar kan şekeri, idrar şekeri ve plazma glikoprotein düzeylerini azaltmıştır (P < 0,05). Sonuç olarak, tıbbi bitki B. monosperma meyvesinin toz hali şeker hastalığı tedavisi için etkili ve alternatif bir yöntemi olarak düşünülebilir.

Diyabetik insan deneklerinde Butea monosperma meyvesinin hipoglisemik ve hipolipidemik aktivitelerinin değerlendirilmesi

Evaluation of the hypoglycemic activity of local Butea monosperma (Palas papra) fruit in normal and diabetic human volunteers was conducted. Sampling was accomplished in and around the city of Faisalabad, especially at the Khadija Mahmood Trust Hospital and at the University of Agriculture, Faisalabad, Pakistan. Volunteers were categorized into normal and diabetic subjects on the basis of their blood glucose levels. Male and female diabetic volunteers aged between 30 and 60 years participated in the study. All the diabetic volunteers suffered from diabetes type II, i.e. noninsulin- dependent diabetes mellitus (NIDDM). The subjects were divided into 5 groups as follows: Group A - Untreated normal subjects; Group B - Normal subjects who received powdered B. monosperma (3 g) in 30 mL of water for 30 days, orally; Group C - Control diabetic subjects; Group D - Diabetic subjects who received powdered (3 g) in 30 mL of water for 30 days, orally; and Group E - Diabetic subjects who received a 5-mg tablet b. I. d. of Daonil® (a standard oral antidiabetic drug) in 30 mL of water for 30 days. The oral administration of B. monosperma fruit to diabetic and normal subjects for 30 days decreased (P < 0.05) blood glucose, urine sugar, and plasma glycoprotein levels, as well as the lipid profile and the activity of liver enzymes. In conclusion, the powder of the medicinal plant B. monosperma fruit can be considered an effective and alternative treatment for diabetes.

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