Gunasekaran BALAMURUGAN, P. MURALIDHARAN, Satyanarayana POLAPALA

Aphrodisiac activity and curative effects of Pedalium murex (L.) against ethanol-induced infertility in male rats

Kronik etanole maruz kalmanın erkeklerde testislerde hasara ve kısırlığa neden olduğu öne sürüldü. Pedaliaceae familyasına ait olan Pedalium murex’in petrol eter özütü (PEPM) bu çalışmada erkek rat modellerinde afrodizyak aktivitesindeki artış yeteneği ve etanolün neden olduğu germ hücre zararı ve kısırlığı tedavi etmek için değerlendirildi. PEPM’ in 200 ve 400 mg/kg dozlarında çiftleşme ve binme davranışında önemli bir artış (P < 0,01, P < 0,001) görüldü. Toplam vücut ağırlığı, hamilelik yüzdesi ve çöp boyutu gibi doğurganlık üzerindeki etkisi de etanol uygulanmış grup ile karşılaştırıldığında önemli ölçüde (P < 0,01) artmıştır. Sperm hareketliliği ve sayısındaki önemli bir artış da doza bağlı şekilde PEPM uygulanmış gruplarda gözlendi (P < 0,01; P < 0,001). Benzer şekilde, anormal spermlerin yüzdesindeki azalmalar 400 mg/kg PEPM ile muamele edilmiş hayvanlarda dikkati çekti. PEPM’ nin toplam protein, toplam kolesterol ve testosteron üzerine etkisi tatmin ediciydi, seviyeleri protein için (P < 0,05), kolesterol için (P < 0,01) ve testosteron için (P < 0,05) 400 mg/kg PEPM konsantrasyonunda önemli derecede arttı. 400 mg/kg PEPM ile muamele edilmiş hayvanların testislerinin mikrotom kesitlerinde onarım gözlendi ve tohum hücrelerinin ve luminal spermatozoaların yeniden kazanımları kontrol grubu hayvanlar ile karşılaştırıldı. TEPM’nin bu etkisi bu bitkiyi ideal bir afrodisiak yapar ve bu bitkide fertiliteyi artırma potansiyeli olan bir ilaç olabilir.

Erkek ratlarda etonolün neden olduğu kısırlığa karşı Pedalium murex (L.)’ın ilaç etkisi ve afrodizyak aktivitesi

It has been suggested that chronic ethanol exposure may result in testicular damage and infertility in males. Petroleum ether extract of Pedalium murex, family Pedaliaceae (PEPM), is evaluated in this study for its ability to increase aphrodisiac activity and to cure ethanol induced germ cell damage and infertility in male rat models. Doses of 200 and 400 mg/kg of PEPM showed a significant increase (P < 0.01, P < 0.001) in mating and mounting behaviour. The effect on fertility factors such as total body weight, percentage of pregnancy, litter size were also significantly increased (P < 0.01) in comparison with the ethanol-treated group. Significant increases in sperm motility and count were observed in PEPMtreated groups in a dose-dependent manner (P < 0.01; P < 0.001) as compared with the ethanol-treated group. Similarly, reductions in the percentage of abnormal sperm were noted in animals treated with PEPM 400 mg/kg. The effects of PEPM on total protein, total cholesterol and testosterone were satisfactory, the levels being increased significantly for protein (P < 0.05), cholesterol (P < 0.01) and testosterone (P < 0.05) by 400 mg/kg PEPM. Microtome sections of the testes of animals treated with 400 mg/kg PEPM exhibited restoration and recovery of germinal cells and the luminal spermatozoa and were comparable with the control group animals. These effects of PEPM make this natural herb ideal as an aphrodisiac and a potent fertility enhancing drug.

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