Mehmet OZANSOY, Mehmet Ozgen ALTİNTAS, Muzaffer Beyza OZANSOY, Necmeddin GUNAY, Ertugrul KİLİC, Ulkan KİLİC

48113

Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model

Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity. Here, we investigated the possible effects of 2 boron-containing compounds-sodium borate decahydrate and boric acid-against amyloid-beta toxicity. In our in vitro amyloid-beta toxicity model, we showed that these 2 compounds increase the survival of the SH-SY5Y cells. Furthermore, boron in these 2 forms increases the expression of Sirt1, which has protective functions against cellular stress. The compounds also change the expressions of GSK-3 alpha/beta; by doing so, boron may contribute to the stimulation of intracellular prosurvival pathways. This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model.
Keywords:

Boron, neuronal survival, amyloid-beta, Sirt1, GSK-3α/β,

PDF

___

  • Aysan E, 2011, INT J MED SCI, V8, P653, DOI 10.7150/ijms.8.653
  • Bennett DA, 2004, ARCH NEUROL-CHICAGO, V61, P378, DOI 10.1001/archneur.61.3.378
  • Blennow K, 2006, LANCET, V368, P387, DOI 10.1016/S0140-6736(06)69113-7
  • DEITRICH RA, 1967, ARCH BIOCHEM BIOPHYS, V119, P253, DOI 10.1016/0003-9861(67)90452-3
  • Donmez G, 2010, AGING CELL, V9, P285, DOI 10.1111/j.1474-9726.2010.00548.x
  • Elibol B, 2019, ADV CLIN TOXICOLOGY, V4, P1, DOI [10.23880/act-16000175, DOI 10.23880/ACT-16000175]
  • Gotz J, 2010, NEURODEGENER DIS, V7, P10, DOI 10.1159/000283475
  • Howe PD, 1998, BIOL TRACE ELEM RES, V66, P153, DOI 10.1007/BF02783135
  • HUNT CD, 1988, BIOL TRACE ELEM RES, V16, P97, DOI 10.1007/BF02797095
  • Hunt CD, 2012, J TRACE ELEM MED BIO, V26, P157, DOI 10.1016/j.jtemb.2012.03.014
  • Khan MS, 2016, NEUROCHEM INT, V100, P1, DOI 10.1016/j.neuint.2016.08.005
  • Kim D, 2007, EMBO J, V26, P3169, DOI 10.1038/sj.emboj.7601758
  • Larson B, 2016, BIOTEK INSTRUMENTS T .
  • Michan S, 2007, BIOCHEM J, V404, P1, DOI 10.1042/BJ20070140
  • Nielsen FH, 1997, PLANT SOIL, V193, P199, DOI 10.1023/A:1004276311956
  • Penland JG, 1998, BIOL TRACE ELEM RES, V66, P299, DOI 10.1007/BF02783144
  • Rahman S, 2011, CELL COMMUN SIGNAL, V9, DOI 10.1186/1478-811X-9-11
  • Sadigh-Eteghad S, 2015, MED PRIN PRACT, V24, P1, DOI 10.1159/000369101
  • Selkoe DJ, 2016, EMBO MOL MED, V8, P595, DOI 10.15252/emmm.201606210
  • Shankar GM, 2008, NAT MED, V14, P837, DOI 10.1038/nm1782
  • STRITTMATTER P, 1964, J BIOL CHEM, V239, P3043
  • Sutherland B, 1998, BIOL TRACE ELEM RES, V66, P193, DOI 10.1007/BF02783138
  • WHO, 1996, TRAC EL HUM NUTR HLT .
Turkish Journal of Biology-Cover
  • ISSN: 1300-0152
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Maryam SAEİDİ, Reza ZAREİE

Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model

Ülkan KILIÇ, Mehmet OZANSOY, Ertuğrul KILIÇ, Muzaffer Beyza OZANSOY, Mehmet Özgen ALTINTAŞ, Necmeddin GÜNAY

Ameera S. ALSHİNNAWY, Wael M. EL-SAYED, Alshaimaa M. TAHA, Ahmed A. SAYED, Ahmed M. SALEM

Poly (I:C)- and doxorubicin-loaded magnetic dendrimeric nanoparticles affect the apoptosis-related gene expressions in MCF-7 cells

Ufuk GÜNDÜZ, Rouhollah KHODADUST, Aktan ALPSOY, Gözde ÜNSOY

Prediction, isolation, overexpression and antifungal activity analysis of Medicago truncatula var. truncatula putative thaumatin like proteins (TLP-1,-2,-3,-4 and-5)

Maryam SAEİDİ, Reza ZAREİE

Model prediction of a Kunitz-type trypsin inhibitor protein from seeds of Acacia nilotica L. with strong antimicrobial and insecticidal activity

Muhammad IMRAN, Ahmed AKREM, Qamar SAEED, Sohaib MEHMOOD, Arslan ALI, Aisha MUNAWAR, Binish KHALIQ, Farzeen ANWAR, Friedrich BUCK, Saber HUSSAIN, Ahsan SAEED, Muhammad YASIN ASHRAF

Taha Bartu HAYAL, Aysegul DOGAN, Hatice Burcu SİSLİ, Binnur KİRATLİ, Fikrettin SAHİN

Simultaneous production of alpha and beta amylase enzymes using separate gene bearing recombinant vectors in the same Escherichia coli cells

Dilek ÖZCAN, Hikmet Murat SİPAHİOĞLU

Mustafa Gorkem OZYURT, Ece BAYİR, Sule DOGAN, Sukru OZTURK, Aylin SENDEMİR

Mehmet OZANSOY, Mehmet Ozgen ALTİNTAS, Muzaffer Beyza OZANSOY, Necmeddin GUNAY, Ertugrul KİLİC, Ulkan KİLİC