Zeynep DEMİRTAŞ, FATİH BİLGİ, LEVENT MERCAN

Memelilerde Genomik Damgalanmanın Epigenetik Düzenleyicileri

Genomik damgalanma, bir genin maternal ya da paternal kökenine bağlı olarak homolog kromozomlardan yalnız bir allelindeki genin ifade edilmesidir. Damgalanma etkisi altında olan çok sayıda genin memelilerin gelişiminde önemli rol oynadığı tespit edilmiştir. Damgalanmış olduğu tespit edilen ilk üç gen fare genomunda keşfedilen Igf2r, Igf2 ve H19 'dur. Günümüzde memelilerde 100'den fazla damgalanmış gen tanımlanmıştır. Damgalanmış genlerin birçoğunun büyüme ve farklılaşma için anahtar role sahip olduğu düşünülmektedir. Bu derlemede memelilerde damgalanmış genlerin epigenetik düzenleyicilerinden bahsedilmiştir.

Epigenetics Regulators of Genomic Imprinting in Mammals

Genomic imprinting is expression of gene's only one allele in one of homolog chromosome depending on its maternal or paternal origin. A waste number of genes which are under the imprinting effect were identified as it has a key role in mammalian growth. The first three genes which is identified as imprinted are Igf2r, Igf2 and H19 which are first discovered in mouse genome. Over a hundred genes are identified as imprinted in mammals. Most of the imprinted genes are considered as they have a key role in growth and differentiation. In this review, epigenetic regulators of imprinted genes in mammals were mentioned.

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