Kanatlı Hayvan Beslemede Antimikrobiyal Peptidlerin Kullanılabilirliği

Kanatlı hayvan beslemede büyütme faktörü olan antibiyotiklere alternatif olarak son yıllarda antimikrobiyal özellikleri tespit edilen peptidler üzerinde çalışılmaya başlanmıştır. Yeme veya suya ilave edilebilen bu peptidler sadece bakterilere karşı değil mantarlara, virüslere ve parazitlere karşı da etkilidirler. Bu makalede antimikrobiyal peptidlerin tanımı, yapıları, çeşitleri, üretim kaynakları, uygulama alanları, etki ettikleri mikroorganizmalar, etki mekanizması ve kanatlı hayvan beslemede kullanımına ilişkin yapılmış çalışmalar hakkında bilgi verilecektir.

Usability of Antimicrobial Peptides in Poultry Nutrition

Peptides with antimicrobial properties as an alternative to antibiotics antibiotic growth promoters in poultry nutrition have been studied in recent years.These peptides, which can be supplemented to diet or water, are effective not only against bacteria but also against fungi, viruses and parasites. In this article, the definition, the structures, the types, the sources of production, the application areas, the microorganisms they act on and the mechanism of action of antimicrobial peptides and information about the studies related to their use in poultry nutrition will be given.

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Akyar I, Rota S. 1999. Geniş spektrumlu doğal antibiyotikler: Katyonik peptidler. Flora, 4(1): 26-33.

Alan AR, Blowers A, Earle ED. 2004. Expression of a magainintype antimicrobial peptide gene (MSI-99) in tomato enhances resistance to bacterial speck disease. Plant Cell Reports, 22: 388–396.

Arakawa T. 2003. Chitin synthesis inhibiting antifungal a gents promote nucleopolyhedrovirus infection in silkworm, Bombyx mori (Lepidoptera: Bombycidae) larvae. Journal of Invertebrate Pathology, 83(3): 261-263.

Aşkar Ş, Aşkar TK. 2017. Antimikrobiyel proteinler ve bağışıklıktaki önemi. Balıkesir Sağlık Bilimleri Dergisi, 6(2): 82-86.

Baltzer SA, Brown MH. 2011. Antimicrobial peptides-promising alternatives to conventional antibiotics. Journal of Molecular Microbiology and Biotechnology, 20(4): 228-235.

Bao H, She R, Liu T, Zhang Y, Peng KS, Luo D, Zhai L. 2009. Effects of pig antibacterial peptides on growth performance and intestine mucosal immune of broiler chickens. Poultry Science, 88(2): 291-297.

Bradshaw JP. 2003. Catiyonic antimicrobial peptides. Bio Drugs, 17(4): 233-240.

Brogden KA, Ackermann M, McCray PB, Tack BF. 2003. Antimicrobial peptides in animals and their role in host defences. International Journal of Antimicrobial Agents, 22: 465-478.

Brodgen KA. 2005. Antimicrobial peptides: pore formes or metabolic inhibitors in bacteria. Natura Reviews / Microbiology, 3: 239-250.

Brogden, NK, Brogden KA. 2011. Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals. International Journal of Antimicrobial Agents, 38(3): 217-225.

Cerovsky V, Budesínsky M, Hovorka O, Cvacka J, Voburka Z, Slaninova J. 2009. Lasioglossins: three novel antimicrobial peptides from the venom of the eusocial bee Lasioglossum Laticeps (Hymenoptera: Halictidae). ChemBioChem, 10: 2089-2099.

Chakrabarti A, Ganapathi TR, Mukherjee PK, Bapat VA. 2003. MSI-99, A magainin analogue, imparts enhanced disease resistance in transgenic tobacco and banana. Planta, 216(4): 587-596.

Chiou PP, Lin CM, Perez L, Chen TT. 2002. Effect of cecropin b and a synthetic analogue on propagation of fish viruses in vitro. Marine Biotechnology, 4(3): 294-302.

Choi SC, Ingale SL, Kim JS, Park YK, Kwon IK, Chae BJ. 2013a. Effects of dietary supplementation with an antimicrobial peptide-p5 on growth performance, nutrient retention, excreta and intestinal microflora and intestinal morphology of broilers. Animal Feed Science and Technology, 185(1-2): 78-84.

Choi SC, Ingale SL, Kim JS, Park YK, Kwon IK, Chae BJ. 2013b. An antimicrobial peptide-a3: effects on growth performance, nutrient retention, intestinal and faecal microflora and intestinal morphology of broilers. British Poultry Science, 54(6): 738-746.

Cole K, Farnell MB, Donoghue AM, Stern NJ, Svetoch EA, Eruslanov BN, Volodina LI, Kovalev YN, Perelygin VV, Mitsevinch EV. 2006. Bacteriocins reduce Compylobacter colonization and alter gut morphology in turkey poults. Poultry Science, 8(6): 1570-1575.

Delves-Broughton J. 2005. Nisin as a food preservative. Food Australia, 57(12): 525-527.

Duru İ, Saçaklı P. 2017. İmmun sistemin silahı: Antimikrobiyal peptidler-bakteriyosinler. 4. Uluslarası Beyaz Et Kongresi Kongre Kitabı. 26-30 Nisan, 698-703, Antalya.

Gao AG, Hakimi SM, Mittanck CA, Wu Y, Woerner BM, Stark DM, Rommens CM. 2000. Fungal pathogen protection in potato by expression of a plant defensin peptide. Nature Biotechnology, 18(12): 1307.

Gürpınar S, Kırkan Ş. 2010. Antimikrobiyel peptidler. İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 36(2): 61-66.

Hancock RE, Scott MG. 2000. The role of antimicrobial peptides in animal defenses. Proceedings of The National Academy of Sciences, 97(16): 8856-8861.

Hu F, Gao X, She R, Chen J, Mao J, Xiao P, Shi R. 2017. Effects of antimicrobial peptides on growth performance and small intestinal function in broilers under chronic heat stress. Poultry Science, 96(4): 798-806.

Izadpanah A, Gallo RL. 2005. Antimicrobial peptides. Journal of the American Academy of Dermatology, 52(3): 381-390.

Jia X, Patrzykat A, Devlin RH, Ackerman PA, Iwama GK, Hancock REW. 2000. Antimicrobial peptides protect coho salmon from vibrio anguillarum infections. Applied and Environmental Microbiology, 66(5): 1928-1932.

Jozefiak D, Sip A, Rutkowski A, Rawski M, Kaczmarek S, Wołuń-Cholewa M, Hojberg O. 2012. Lyophilized Carnobacterium divergens AS7 bacteriocin preparation improves performance of broiler chickens challenged with Clostridium perfringens. Poultry Science, 91(8): 1899-1907.

Koo JC, Chun HJ, Park HC, Kim MC, Koo YD, Koo SC, Lim CO. 2002. Over-expression of a seed specific hevein-like antimicrobial peptide from pharbitis nil enhances resistance to a fungal pathogen in transgenic tobacco plants. Plant Molecular Biology, 50(3): 441-452.

Keymanesh K, Soltani S, Sardari S. 2009. Application of antimicrobial peptides in agriculture and food industry. World Journal of Microbiology and Biotechnology, 25(6): 933-944.

Leite JRS, Silva LP, Rodrigues MIS, Prates MV, Brand GD, Lacava BM, Bloch Jr C. 2005. Phylloseptins: A novel class of anti-bacterial and anti-protozoan peptides from the phyllomedusa genus. Peptides, 26(4): 565-573.

Li Y, Xiang Q, Zhang Q, Huang Y, Su Z. 2012. Overview on the recent study of antimicrobial peptides: Origins, functions, relative mechanisms and application. Peptides, 37(2): 207- 215.

Liu T, She R, Wang K, Bao H, Zhang Y, Luo D, Peng K. 2008. Effects of rabbit sacculus rotundus antimicrobial peptides on the intestinal mucosal immunity in chickens. Poultry Science, 87(2): 250-254.

Ohh SH, Shinde PL, Choi JY, Jin Z, Hahn TW, Lim HT, Chae BJ. 2010. Effects of potato (Solanum Tuberosum I. Cv. Golden Valley) protein on performance, nutrient metabolizability, and cecal microflora in broilers. Archiv Für Geflügelkunde, 74(1): 30-35.

Özcan MA, Gülüm L, Midilli M, Gören M. 2019. The using of antimicrobial peptides in broiler feeding. Turkish Journal of Agriculture-Food Science and Technology, 7(1): 1-6.

Pawar DD, Malik SVS, Bhilegaonkar KN, Barbuddhe SB. 2000. Effect of nisin and its combination with sodium chloride on the survival of Listeria monocytogenes added to raw buffalo meat mince. Meat Science, 56(3): 215-219

Reuveni M, Cohen H, Zahavi T, Venezian A. 2000. Polar-a potent Polyoxin B compound for controlling powdery mildews in apple and nectarine trees, and grapevines. Crop Protection, 19(6): 393-399.

Sharma A, Sharma R, Imamura M, Yamakawa M, Machii H. 2000. Transgenic expression of cecropin B, an antibacterial peptide from Bombyx mori, confers enhanced resistance to bacterial leaf blight in rice. FEBS Letters, 484(1): 7-11.

Smet KD, Contreras R. 2005. Human antimicrobial peptides: Defensins, cathelicidins and histatins. Biotechnology Letters, 27(18): 1337-1347.

Tuncer Hİ. 2007. Karma yemlerde kullanımı yasaklanan hormon, antibiyotik, antikoksidiyal ve ilaçlar. Lalahan Hayvancılık Araştırma Enstitüsü Dergisi, 47(1): 29-37.

Vasilchenko AS, Rogozhin EA, Vasilchenko AV, Kartashova OL, Sycheva MV. 2016. Novel haemoglobin‐derived antimicrobial peptides from chicken (Gallus gallus) Blood: Purification, structural aspects and biological activity. Journal of Applied Microbiology, 121(6): 1546-1557.

Vidal JR, Kikkert JR, Malnoy MA, Wallace PG, Barnard J, Reisch BI. 2006. Evaluation of transgenic ‘Chardonnay’(Vitis vinifera) containing magainin genes for resistance to crown gall and powdery mildew. Transgenic Research, 15(1): 69- 82. Vylkova S, Nayyar N, Li W, Edgerton M. 2007. Human betadefensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption. Antimicrobial Agents and Chemotherapy, 51(1): 154-161.

Wang D, Ma W, She R, Sun Q, Liu Y, Hu Y, Liu L, Yang Y, Peng K. 2009. Effects of swine gut antimicrobial peptides on the intestinal mucosal immunity in specific-pathogen-free chickens. Poultry Science, 88(5): 967-974.

Wang S, Zeng XF, Wang QW, Zhu JL, Peng Q, Hou CL, Thacker P, Qiao SY. 2015. The antimicrobial peptide sublancin ameliorates necrotic enteritis induced by Clostridium perfringens in broilers. Journal of Animal Science, 93(10): 4750-4760.

Wang S, Zeng X, Yang Q, Qiao S. 2016. Antimicrobial peptides as potential alternatives to antibiotics in food animal industry. International Journal of Molecular Sciences, 17(5): 603-615.

Wen LF, He JG. 2012. Dose-response effects of an antimicrobial peptide, a cecropin hybrid, on growth performance, nutrient utilisation, bacterial counts in the digesta and intestinal morphology in broilers. British Journal of Nutrition, 108(10): 1756-1763.

Yevtushenko DP, Romero R, Forward BS, Hancock RE, Kay WW, Misra S. 2005. Pathogen-ınduced expression of a cecropin a-melittin antimicrobial peptide gene confers antifungal resistance in transgenic tobacco. Journal of Experimental Botany, 56(416): 1685-1695.

Yıbar A, Soyutemiz E. 2013. Gıda değeri olan hayvanlarda antibiyotik kullanımı ve muhtemel kalıntı riski. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, 8(1): 97-104.

Yurong Y, Yibao J, Ruiping S, Qingqiang Y, Kaisong P, Huihui B, Decheng W, Tianlong L, Xuemei Z. 2006. Effects of chicken intestinal antimicrobial peptides on humoral immunity of chickens and antibody titres after vaccination with infectious bursal disease virus vaccine in chicken. Archives of Animal Nutrition, 60(5): 427-435.

Zhang JX, Zhang SF, Wang TD, Guo XJ, Hu RL. 2007. Mammary gland expression of antibacterial peptide genes to inhibit bacterial pathogens causing mastitis. Journal of Dairy Science, 90(11): 5218-5225.
Türk Tarım - Gıda Bilim ve Teknoloji dergisi-Cover
  • ISSN: 2148-127X
  • Yayın Aralığı: Aylık
  • Başlangıç: 2013
  • Yayıncı: Turkish Science and Technology Publishing (TURSTEP)
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