Chemical Constituents of Essential oil of Syringa vulgaris L. flowers

Medicinal plants gain a great interest in drug development process due to their bioactive compounds content. Syringa vulgaris L. has been used as traditional medicine and it has considerable biological effects. In this study, essential oil (EO) was generated from Syringa vulgaris L. flowers by hydrodistillation and the chemical constituents were identified by GC/MS/MS analysis. The GC/MS/MS analysis revealed the presence of 57 compounds, and linalool (26.34%), α-terpineol (10.84%), trans geraniol (9.83%), α-bisabolol (4.50%), cis-nerol acetate (5.28%), lavandulyl acetate (4.32%) were found as major products.

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Adams RP. 2007. Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry. Illinois, USA: Allured Publishing Corporation, Carol Stream.
Akgül H, Mohammed FS, Kına E, Uysal İ, Sevindik M, Doğan M. 2022. Total Antioxidant and Oxidant Status and DPPH Free radical activity of Euphorbia eriophora. Turkish Journal of Agriculture-Food Science and Technology. 10: 272-75.
Aksit H, Çelik SM, Sen Ö, Erenler R, Demirtas I, et al. 2014. Complete isolation and characterization of polar portion of Mentha dumetorum water extract. Records of Natural Products. 8: 277-80.
Bayir B, Gündüz H, Usta T, Şahin E, Özdemir Z, et al. 2014. Chemical Composition of Essential Oil from Marrubium Vulgare L. Leaves. Journal of New Results in Science. 6: 44- 50.
Demirtas I, Erenler R, Elmastas M, Goktasoglu A. 2013. Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry. 136: 34-40.
Elmastas M, Celik SM, Genc N, Aksit H, Erenler R, Gulcin İ. 2018. Antioxidant activity of an anatolian herbal tea— Origanum minutiflorum: isolation and characterization of its secondary metabolites. International Journal of Food Properties. 21: 374-84.
Erenler R, Adak T, Karan T, Elmastas M, Yildiz I, et al. 2017a. Chemical Constituents isolated from Origanum solymicum with Antioxidant activities. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics. 1: 139- 45.
Erenler R, Demirtas I, Karan T, Gul F, Kayir O, Karakoc OC. 2018. Chemical constituents, quantitative analysis and insecticidal activities of plant extract and essential oil from Origanum onites L. Trends in Phytochemical Research. 2: 91- 96.
Erenler R, Meral B, Sen O, Elmastas M, Aydin A, et al. 2017b. Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. Pharmaceutical Biology. 55: 1646-53.
Erenler R, Sen O, Aksit H, Demirtas I, Yaglioglu AS, et al. 2016. Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture. 96: 822-36.
Erenler R, Yilmaz S, Aksit H, Sen O, Genc N, et al. 2014. Antioxidant activities of chemical constituents isolated from Echinops orientalis Trauv. Records of Natural Products. 8: 32-36.
Guzel A, Aksit H, Elmastas M, Erenler R. 2017. Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden. and Scheng. Pharmacognosy Magazine. 13: 316-20.
Hanganu D, Niculae M, Ielciu I, Olah N-K, Muntean M, et al. 2021. Chemical profile, cytotoxic activity and oxidative stress reduction of different Syringa vulgaris L. extracts. Molecules. 26: Article No 3104.
Kamatou GP, Viljoen AM. 2008. Linalool–A review of a biologically active compound of commercial importance. Natural Product Communications. 3: 1183-92.
Karan T, Simsek S, Yildiz I, Erenler R. 2018. Chemical composition and insecticidal activity of Origanum syriacum L. essential oil against Sitophilus oryzae and Rhyzopertha dominica. International Journal of Secondary Metabolite. 5: 87-93.
Kaya G, Karakaya R, Tilgel E, Sandikci M, Yucel E, et al. 2014. Essential Oil Constituents of Thuja orientalis Berries. Journal of New Results in Science. 7: 1-6.
Kına E, Uysal İ, Mohammed FS, Doğan M, Sevindik M. 2021. In-vitro antioxidant and oxidant properties of Centaurea rigida. Turkish Journal of Agriculture-Food Science and Technology. 9: 1905-07.
Korkmaz N, Dayangaç A, Sevindik M. 2021. Antioxidant, antimicrobial and antiproliferative activities of Galium aparine. Journal of Faculty of Pharmacy of Ankara University. 45: 554-64.
Mohammed FS, Kına E, Sevindik M, Doğan M, Pehlivan M. 2021. Antioxidant and antimicrobial activities of ethanol extract of Helianthemum salicifolium (Cistaceae). Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural Product Radiance (NPR)]. 12: 459-62.
Sahin Yaglioglu A, Akdulum B, Erenler R, Demirtas I, Telci I, Tekin S. 2013. Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots. Medicinal Chemistry Research. 22: 2946-53.
Savelev S, Okello E, Perry N, Wilkins R, Perry E. 2003. Synergistic and antagonistic interactions of anticholinesterase terpenoids in Salvia lavandulaefolia essential oil. Pharmacology Biochemistry and Behavior. 75: 661-68.
Stein S, Mirokhin D, Tchekhovskoi D, Mallard G, Mikaia A, et al. 2002. The NIST mass spectral search program for the NIST/EPA/NIH mass spectra library. Gaithersburg, MD: Standard Reference Data Program of the National Institute of Standards and Technology. Gaithers-Burg, MD, US. Topçu G, Erenler R, Çakmak O, Johansson CB, Çelik C, et al. 1999. Diterpenes from the berries of Juniperus excelsa. Phytochemistry. 50: 1195-99.
Türkmen N, Öz A, Sönmez A, Erol T, Gülümser D, et al. 2014. Chemical Composition of Essential Oil from Rosmarinus Officinalis L. Leaves. Journal of New Results in Science. 6: 27-31.
Varga E, Barabás C, Tóth A, Boldizsár I, Noszál B, Tóth G. 2019. Phenolic composition, antioxidant and antinociceptive activities of Syringa vulgaris L. bark and leaf extracts. Natural Product Research. 33: 1664-69.
Woźniak M, Michalak B, Wyszomierska J, Dudek MK, Kiss AK. 2018. Effects of phytochemically characterized extracts from Syringa vulgaris and isolated secoiridoids on mediators of inflammation in a human neutrophil model. Frontiers in Pharmacology. 9: Article No 349.
Yan Y, Wuliji O, Zhao X, Ye X, Zhang C, et al. 2010. Effect of essential oil of Syringa pinnatifolia Hemsl. var. alashanensis on Ischemia of myocardium, hypoxia and platelet aggregation. Journal of Ethnopharmacology. 131: 248-55.
Yildiz I, Sen O, Erenler R, Demirtas I, Behcet L. 2017. Bioactivity–guided isolation of flavonoids from Cynanchum acutum L. subsp. sibiricum (willd.) Rech. f. and investigation of their antiproliferative activity. Natural Product Research. 31: 2629-33.