Ertuğrul ÇOLAK, Enver ŞİMŞEK, Birgül KİREL, Rabia TOKER TÜTÜNCÜ

Şişman çocuk ve ergenlerde alkolik olmayan yağlı karaciğer hastalığı

Amaç: Şişman çocuklarda alkolik olmayan yağlı karaciğer hastalığı sıklığı ve ilişkili olduğu etmenleri araştırmak.Gereç ve Yöntem: Polikliniğimizde hepatobiliyer ultrasonografi ile yağlı karaciğer hastalığı varlığının araştırıldığı, 161 şişman çocuğun (4-18 yaş) dosyaları geriye dönük olarak incelendi. Fizik muayene bulguları, antropometrik ölçümler, akantozis nigrikans, pubertal gelişimleri ve laboratuvar tetkiklerine ait kayıtları değerlendirildi. Çalışma protokolü için Osmangazi Üniversitesi Etik Kurulu’ndan onay alındı (2010/13).Bulgular: Ultrasonografi ile hastaların %40’ında hepatosteatoz saptandı. Steatozlu olanların %35’inde serum alanin aminotransferaz düzeyi ≥40 U/L idi. Steatozlu olanlarda (olmayanlara göre) vücut kitle indeksi, HOMA-IR (Homeostasis model of assessment-insulin resistance), alanin aminotransferaz, aspartat aminotransferaz, insulin and trigliserit düzeyleri ve akantozis nigrikans sıklığı yüksek, HDL-C düzeyleri düşük bulundu. Alanin aminotransferaz düzeyi yüksek olanlarda trigliserit düzeyi yüksek iken HDL-C düzeyi düşük idi. Kızların %32’sinde, erkeklerin %54’ünde steatoz vardı (p

Nonalcoholic fatty liver diseases in obese children and adolescents

Aim: To determine the prevelance of the non-alcoholic fatty liver in obese children. Material and Method: Medical records of 161 obese children (age 4-18 yrs) who were investigated for non-alcoholic fatty liver by USG were analysed retrospectively. Their findings of physical examination and antropometric measurements, presence of acanthosis nigricans, pubertal status and results of laboratory analysis were evaluated. The study protocol was approved by the Osmangazi University Ethical Committee (2010/13). Results: Hepatosteatosis was found in 40% of the patients by ultrasonography. Elevation of serum alanine aminotransferase (≥40 U/L) was found in 35% of the patients with steatosis. These patients had higher body mass index, HOMA-IR (Homeostasis model of assessment-insulin resistance) and aspartat aminotransferase, alanine aminotransferase, insulin and triglyceride levels and lower HDL-C levels and higher acanthosis nigricans prevalences than the patients without steatosis. Patients with elevated alanine aminotransferase levels had significantly higher trygliceride and lower HDL-C levels than the patients with normal alanine aminotransferase levels. Steatosis prevalences were 32% in girls and 54% in boys (p

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