Mini puberte ve yorumlanması

Fetal hayatın ortalarında yüksek düzeyde seyreden gonadotropin- ler kordon kanında oldukça düşük, östrojen yüksek düzeylerde öl- çülmektedir. Yüksek östrojen ile gonadotropinler baskılanmaktadır. Doğumdan sonra plasental östrojen devreden çıkınca hipotalamo- pituiter-gonadal aks aktive olur ve pubertal düzeylere ulaşan hor- mon profili oluşur. Bu değişimlere mini puberte adı verilir. Erkek çocuklarda mini puberte ile ileri dönem testis işlevleri, sperm yapımı düzenlenir, beynin maskülinizasyonuna katkıda bulunur. Kız yeni- doğanlarda mini pubertenin tam rolü bilinmemektedir. Mini puber- tenin değerlendirilmesiyle, merkezi hipogonadizm, Turner sendro- mu ve erken doğmuş bebeklerde ovariyen aşırı uyarılma tanılarına gidilebilir. Yazıda mini puberte ve ilişkili sorunlar gözden geçirilmiş ve bu konunun önemi vurgulanmıştır. (Türk Ped Arş 2014; 49: 186-91)

Mini puberty and its interpretation

Gonadotropins which are high in the middle of the fetal life are measured to be considerably low in the cord blood and estrogen is found to be high in the cord blood. Gonodotropins are supressed by estrogen. After delivery, the hypothalamo-pituitary-gonadal axis is activated when estrogen is eliminated and a hormone profile which reaches pubertal levels is established. These changes are called mini puberty. In boys, long-term testicular functions and sperm produc- tion are regulated with mini puberty and mini puberty contributes to masculinization of the brain. The role of mini puberty in female newborns is not known. Central hypogonadism, Turner syndrome and ovarian hyperstimulation in preterm babies may be diagnosed with evaluation of mini puberty. In this article, mini puberty and re- lated problems were reviewed and the importance of this issue was emphasized. (Türk Ped Arş 2014; 49: 186-91)

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