Hepatosit aktarımı

Karaciğer nakil adayı hastaların sayısının giderek artmasına karşın temin edilebilen kadavra organ sayısının yetersiz kalması yeni tedavi arayışlarını doğurmuştur. Hepatosit aktarımı, organ bekleyen karaciğer nakil adayları için yeni bir umut kaynağıdır. Çoğu kez organ bağışında kullanılamayan, ya da artan karaciğer bölümlerinden elde edilen hepatosit süspansiyonlarının deri yoluyla karaciğer ya da karaciğer dışı ektopik bölgelere uygulanmasıyla gerçekleştirilen hepatosit aktarımı, akut ve kronik karaciğer yetersizliğinde karaciğer nakline köprü oluşturan bir yaklaşım olarak uygulanmaktadır. Son yıllarda karaciğer kaynaklı çeşitli metabolik hastalıkların tedavisine yönelik hepatosit aktarımı uygulamaları da giderek artmıştır. Criggler Najjar sendromu tip 1, glikojen depo hastalıkları, üre döngüsü bozuklukları, peroksizomal hastalıklar ve faktör VII eksikliğinde hepatosit aktarımı ile bildirilen sonuçlar ümit vericidir. Hücre nakline ilişkin teknik sorunlar çözümlenebilirse hepatosit aklarımı karaciğer hastalıklarının yanı sıra metabolik hastalıklar için de geçerli bir tedavi seçeneği oluşturacak gibi gözükmektedir.

Hepatocyte transplantation

New therapeutic strategies have been evolving to solve the problem of organ scarcity despite increasing numbers of patients awaiting for liver transplantation. Hepatocyte transplantation is a promising theraupetic approach for liver transplantation candidates. It is carried out by infusion of hepatocyte suspensions, obtained from organs not suitable for donation, into the liver or ectopic sites using a percutaneous approach. Hepatocyte transplantation is performed as a bridge to liver transplantation in acute or chronic liver failure. In recent years, hepatocyte transplantation has been widely applied in the treatment of various metabolic diseases originating from the liver. Experience with Criggler Najjar syndrome type 1, glycogen storage disease, urea cycle disorders, peroxisomal disorders and factor VII deficiency have been reported. In the future, hepatocyte transplantation may become an alternative treatment for metabolic diseases as well as acute and chronic liver failure provided that the technical problems involving cell transplantation are solved.

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