Fatma Karakuş, Gülcan Türker, Ayşe Sevim Gökalp

Erken aminoasit desteğinin çok düşük doğum ağırlıklı bebeklerin büyüme ve nörolojik gelişimi üzerine etkisi Özgün Araştırma

Özet Amaç: Erken aminoasit desteğinin 32 gebelik haftasının altında doğan bebeklerde postmenstrüel 36 hafta ve düzeltilmiş yaşa göre 18 aylarında nörolojik gelişim ve büyüme üzerine etkilerini değerlendirmektir nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; Gereç ve Yöntem: Hayatlarının ilk beş gününde ge;3 gr kg gün parenteral aminoasit alan bebekler erken grubu 3 gr kg gün rsquo;den daha az alanlar geç grubu oluşturdu Ağırlık boy baş çevresi ölçümleri postmenstruel 36 hafta ve düzeltilmiş yaş 18 ayda yapıldı Nörolojik değerlendirmede Bayley gelişim testi uygulandı nbsp; Bulgular: Erken ve geç gruplar arasında doğum ağırlığı arasında fark varken diğer temel belirgin özellikler açısından fark saptanmadı 36 gebelik haftasında ve düzeltilmiş yaşa göre 18 aylarında her iki grup arasında boy baş çevresi ve ağırlık açısından fark saptanmadı Erken grupta kızların 36 hafta ve 18 ayda baş çevre ölçümlerinin daha iyi olduğu görüldü Bayley mental ve psikomotor gelişim indeksi ile nörogelişimsel bozulma yönünden farklılık saptanmadı Çıkarımlar: Erken grupta doğum ağırlığının düşük olmasına rağmen 36 haftada ve 18 ayda geç grup seviyelerini yakalamış olması ve kızlarda daha iyi baş çevresinin elde edilmesinin erken aminoasit desteğinin büyüme ve nörogelişim üzerine olumlu etkisinin olduğunu düşündürmektedir Türk Ped Arş 2010; 45: 111 8 Anahtar sözcükler: Erken doğmuş bebek erken parenteral aminoasit erken doğmuş bebeğin büyümesi sinir sistemi gelişimi nbsp;

Anahtar Kelimeler:

Erken doğmuş bebek, erken parenteral aminoasit, erken doğmuş bebeğin büyümesi, sinir sistemi gelişimi

The effect of early parenteral amino acids on growth and neurodevelopment of very low birth weight infants Original Article

Summary Aim: To assess the effect of early parenteral amino acids on growth and neurodevelopment of very low birth weight infants at 36 weeks rsquo; postmenstrual age and 18 months rsquo; corrected age nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; nbsp; Material and Method: nbsp; Infants who received ge;3 gr kg per day of parenteral amino acids within the first 5 days of life were considered early group; infants who receive lt;3 gr kg per day of parenteral amino acids within the first 5 days of life were considered late group Infants rsquo; weight length and head circumference were measured et 36 weeks rsquo; of postmenstrual age and 18 months rsquo; of corrected age Nerodevelopmental index was evaluated by ldquo;Bayley Scales of Infant Development rdquo; Results: There were no statistically differences between the early and late amino acid groups in baseline characteristics; except birth weight At 36 weeks rsquo; postmenstrual age and 18 months rsquo; corrected age there were no statistically differences in weight length and head circumference between the two groups In the early group female babies had bigger head circumference than male babies at 36 weeks rsquo; postmenstrual age and 18 months rsquo; corrected age There were no other observed differences between boys or girls There were no differences between two groups for neurodevelopmental impairment by Bayley mental and psychomotor developmental index nbsp; Conclusions: On evaluation of head circumferences at 36 weeks rsquo; postmenstrual age and 18 months rsquo; corrected age it is shown that the low birth weight early group catch up with the late group and girls in the early group have bigger head circumference therefore it is suggested that early aminoacid supplementation may have positive effect on growth and neurodevelopmental impact Turk Arch Ped 2010; 45: 111 8 Key words: Premature infant early parenteral amino acid premature growth nbsp; neurodevelopment nbsp;

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