Pınar SOLMAZ HASDEMİR, Tevfik GÜVENAL

BİR ÜNİVERSİTE HASTANESİNDE GESTASYONEL TROFOBLASTİK HASTALIK OLGULARININ DEĞERLENDİRİLMESİ

Amaç: Gestasyonel trofoblastik hastalık (GTH) tanısı almış olguların klinikopatolojik özelliklerinin ve tedavilerinin değerlendirilmesi. Yöntemler: 2003- 2013 yılları arasında kliniğimize GTH tanısı ile yatırılmış olan ve bilgilerine ulaşılan 34 hasta bu çalışmaya alınmıştır. Hastaların demografik, kliniko-patolojik özellikleri ile uygulanan tedavi yöntemleri ve izlem sonuçları retrospektif olarak değerlendirilmiştir. Bulgular: Çalışmamızda 27 adet hidatiform mol (HM) (15 komplet, 12 parsiyel), 7 adet non-metastatik gestasyonel trofoblastik neoplazi (NM-GTN) olgusu değerlendirilmiştir. Olguların yaş ortalaması 31,3± 9,2 yıl, ortalama gebelik sayısı 2,7± 1,5, ortalama doğum sayısı 1,13± 1,03, düşük ve geçirilmiş mol gebelik oranları sırasıyla ortalama 0,3± 0,5 ve 0,1± 0,4 şeklinde idi. HM tanısı almış olguların 3 tanesinde (%8,8) tedavi sonrası mol gebelik tekrarlamış, bunlardan birinde histerektomi, diğer ikisinde tekrar revüzyone küretaj (R/C) ile remisyon sağlanmıştır. NM-GTN tanılı hastaların tümünde tek ajan kemoterapi ile remisyon sağlanmıştır. Sonuç: Gestasyonel trofoblastik hastalık, erken tanı, uygun tedavi ve izlem yapıldığında remisyon oranları yüksektir. Ancak tedaviye bağlı ciddi komplikasyonlar ile karşılaşılabilir.

Anahtar Kelimeler:

Gestasyonel trofoblastik hastalık, mol hidatiform, gestasyonel trofoblastik neoplazi

OUTCOMES OF PATIENTS WITH GESTATIONAL TROPHOBLASTIC DISEASE IN AN UNIVERSITY HOSPITAL

Aim: To investigate the clinicopathologic features and treatment procedures of the patients who diagnosed as Gestational Trophoblastic Disease (GTD). Methods: Thirty-four patients who pre-diagnosed as GTD between the years 2003- 2013 included to this investigation. Descriptive and clinicopathologic features, treatment and follow-up results of the patients investigated retrospectively. Results: Totally 27 hydatiform mole (HM) (15 of them complete and 12 of them partial) and 7 non-metastatic gestational trophoblastic neoplasia (NM-GTN) case was found in 10 years period of time. The mean age of the patients was 331,37± 9,27 (16-52), the pregnancy rate was 2,7± 1,5 (0-7), parity rate was 1,13± 1,03 (0-4), the abortus and history of molar pregnancy rates were 0,35± 0,58 (0-2) ve 0,15± 0,44 (0-2), respectively. Three recurrences (8,8%) was seen in HM cases and two of them needed repeat curettage (R/C) and the other one needed hystetectomy and all the three cases survived. Single agent chemotheraphy was been successful in all the GTN cases. Conclusion: GTD is a curable condition with early diagnosis, adequate management and follow-up. Complications due to treatment should be kept in mind.

Keywords:

hydatidiform mole, gestational trophoblastic disease, gestational trophoblastic neoplasia.,

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