Ömer ARAZ, Canan ATALAY, Yener AYDIN, Hüsnü KÜRŞAD, Ayşenur COŞKUN, Muhammet KARACA, Muhammet Emin NALDAN, Emrullah DORMAN, Ferah DALOĞLU

Akut akciğer hasarında spironolakton ve sürfaktan tedavisinin HMGB1, CRP, IL-1b ve TNF-a düzeyleri üzerine etkisi

Amaç: Bu çalışmada akut akciğer hasarı (AAH) ve akut solunum sıkıntısı sendromunda (ASSS) high-mobility group box-1 (HMGB1), interlökin-1 beta (IL-1b), tümör nekroz faktör alfa (TNF-a) ve C reaktif protein (CRP) düzeyleri ile spironolakton ve surfaktan tedavisi karşılaştırıldı, spironolakton ve surfaktan tedavisinin etkili olup olmadığı araştırıldı ve bu tedavinin akciğerdeki histopatolojik değişiklikler üzerine etkisi değerlendirildi.Çalışmaplanı:Kırk tavşan her bir grupta sekiz tavşan olacak şekilde beş gruba randomize edildi: grup N: normal grup, grup T: trakeostomili grup, grup A: ASSS grubu, grup S1: spironolakton grubu, grup S2: surfaktan grubu. Tavşanların akciğerleri diseke edildi ve histopatolojik olarak incelendi.Bul gu lar: Grup A'da HMGB1, CRP, IL-1b ve TNF-a düzeyleri istatistiksel olarak anlamlı şekilde artmış idi. S1 ve S2 gruplarında HMGB1, CRP, IL-1b ve TNF-a düzeylerinde istatistiksel olarak anlamlı azalma vardı (p

The efficacy of spironolactone and surfactant treatment on HMGB1, CRP, IL- 1b and TNF-a levels in acute lung injury

Background: This study aims to compare high-mobility group box-1 (HMGB1), interleukin-1 beta (IL-1b), tumor necrosis factor alpha (TNF-a), and C reactive protein (CRP) levels with spironolactone and surfactant treatment, investigate if spironolactone and surfactant treatment is effective, and evaluate the effect of this treatment on histopathologic changes in the lungs in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).Methods: Forty rabbits were randomized into five groups to include eight rabbits in each group: group N: normal group, group T: tracheotomized group, group A: ARDS group, group S1: spironolactone group, group S2: surfactant group. Lungs of the rabbits were dissected and examined histopathologically.Results: HMGB1, CRP, IL-1b and TNF-a levels were statistically significantly increased in group A. There was a statistically significant decrease in HMGB1, CRP, IL-1b and TNF-a levels in S1 and S2 groups (p

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