Ramazan Öçalan, Fatma Ceyda Akın Öçalan, Zeliha Korkmaz Dişli

Primer Nazofarengeal Hodgkin Lenfoma: Olgu Sunumu

Hodgkin lenfomaların yaklaşık olarak %1'inden azını primer nazofarengeal tutulum oluşturur. Bu bölgedeki Hodgkin lenfomaların uygun tedavi ile prognozları oldukça iyidir. Bildirilen Hodgkin vakalarının birçoğu evre 1 veya 2' de saptanmıştır. Bilateral burun tıkanıklığı şikayetiyle polikliniğimize başvuran 53 yaşındaki erkek hastanın yapılan endoskopik bakısında nazofarenkste kitlesi saptandı. Hastanın eksizyon sonrası patoloji sonucu ‘klasik tip Hodgkin Lenfoma–nodüler sklerozan' şeklinde raporlandı. Kemik iliği biyopsisi, toraks, abdomen ve boyun bilgisayarlı tomografi (BT) sonuçları normal izlendi. Yapılan Pozitron Emisyon Tomografi (PET) normal sınırlardaydı. Evre 1EA olarak değerlendirilen bu hastaya ardışık radyoterapi ve 6 kür kemoterapi uygulandı. Biz de bu olgunun tanı ve tedavi sürecini literatür eşliğinde sunmayı amaçladık. Anahtar kelimeler: Hodgkin Lenfoma; Nazofarenks; Prognoz.

Anahtar Kelimeler:

Hodgkin Lenfoma; Nazofarenks; Prognoz.

Primary Nasopharyngeal Hodgkins Disease: A Case Report

Primary nasopharyngeal Hodgkin's disease occurs in less than %1 of all Hodgkin's disease cases. With appropriate treatment, the prognosis for this particular type of Hodgkin's Lenfoma is favorable. Most documented cases of Hodgkin's Lenfoma are either stage 1 or 2 patients. A 53-year-old male patient presented with bilateral nasal obstruction. Endoscopic examination of the nasal cavity revealed a mass arising from the nasopharynx. After the excision histopatological study reported the case to be classic Hodgkin's Lenfoma, of a nodular sclerosis type. Bone marrow core biopsy, scanning of chest, abdomen and neck were normal. Further positron emission tomographic scan also showed no abnormalities. The patient was considered to have stage 1EA nasopharyngeal Hodgkin's Lenfoma and was treated with radiotherapy and 6 cycles of chemothreapy. We aim to present this uncommon case of Hodgkin's Lenfoma confined to the nasopharynx with a review of the literature. Key words: Hodgkin's disease; Nasopharynx; Prognosis.

Keywords:

Hodgkin's disease; Nasopharynx; Prognosis.,

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Barton JH, Osborne BM, Butler JJ, Meoz RT, Kong J, Fuller LM et all. Non-Hodgkin’s lymphoma of the tonsil. A clinicopathologic study of 65 cases. Cancer 1984;53:86-95.
Malis DD, Moffat D, McGarry GW. Isolated nasopharyngeal Hodgkin’s disease presenting as nasal obstruction. Int J Clin Pract 1998;52:343-6.
Eavey RD, Goodman ML. Hodgkin’s disease of the nasopharynx. Am J Otol 1982;3:417-21.
Anselmo AP, Cavalieri E, Cardarelli L, Gianfelici V, Osti FM, Pescarmona E et all. Hodgkin’s disease of the nasopharynx: diagnostic and therapeutic approach with a review of the literature. Ann Hematol 2002;81:514-6.
Bjorklund A, Cavallin-Stahl E, Landberg T, Lindberg LG, Ackerman M. Biopsy of the nasopharynx as a staging procedure in Hodgkin’s disease. Acta Radiol Ther Phys Biol 1976;15:387-93.
Bensouda Y, Hassani KE, Ismaili N, Lalya I, Boutayeb S, Benjaafar N et al. Primary nasopharyngeal Hodgkin’s
Journal of Turgut Ozal Medical Center
disease:case report and literature review. J Med Case Report 2010;4:116.
O’Reilly BJ, Kershaw JB. Hodgkin’s disease of the nasopharynx. J Laryngol Otol 1987;101:506-7.
Takashima H, Kawashima K, İsayama Y. Hodgkin lymphoma of the nasopharynx associated with a pituitary adenoma. Rinsho Ketsueki 2003;44:1172-4.
Iyengar P, Mazloom A, Shihadeh F, Berjawi G, Dabaja B . Hodgkin lymphoma involving extranodal and nodal head and neck sites: characteristics and outcomes. Cancer 2010; 116:3825-9.