Dioksinli Bileşiklerin Etki Mekanizması, Kimyasal Yapısı ve Toksikokinetik Özelliklerinin İncelenmesi

Dioksinli bileşikler geniş yayılım alanına sahip, doğada kararlı durumda bulunan, insan ve hayvan sağlığı açısından son derece zehirli çevresel kirleticilerdir. Kimyasal olaylara ve yüksek ısıya bağlı olarak oluşan dioksinli bileşikler özellikle hayvansal gıdalar aracılığı ile insanlar tarafından alınmakta ve yağ dokuda depolanmaktadır. Bu bileşikler, insanlarda kanser başta olmak üzere immunsistem bozuklukları, kloroakne, Wasting sendromu, hormon ve üreme sistemi fonksiyon bozuklukları gibi birçok yan etkiye neden olmaktadır. Toplum sağlığı açısından oluşturabilecekleri riskler göz önüne alınarak, dioksinli bileşiklerin kaynakları, kimyasal yapıları, etki mekanizmaları, zehirlilikleri, kabul edilebilir günlük alım miktarları ve bazı toksikokinetik özelliklerinin bilinmesi oldukça önemlidir. Anahtar kelimeler: Dioksin; 2,3,7,8-TCDD; PCDD; PCDF; PCB.

Anahtar Kelimeler:

Dioksin; 2, 3, 7, 8-TCDD; PCDD; PCDF; PCB.

The Investigation of Effect Mechanism, Chemical Structure and Toxicokinetics Properties of Dioxins Compounds

Dioxin compounds are environmental pollutants that have a wide range of diffusion and that are harmful for human and animal health. The dioxin compounds are formed by some chemical process and high temperature. They are taken by human beings through animal products and then stored in fat tissues. The dioxin compounds have many side effects including immune system disrupts, chloracne, wasting syndrome, endocrine and reproductive toxicity as well as cancer. As considered the risks of dioxins which may affect the public health, it is important to learn about the sources, chemical structures, effect mechanisms, toxicity, the daily intake rates, and toxicokinetics properties of dioxins. Key words: Dioxin; 2,3,7,8-TCDD; PCDD; PCDF; PCB.

Keywords:

Dioxin; 2, 3, 7, 8-TCDD; PCDD; PCDF; PCB.,

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(Poliklorlu dibenzo-para dioksinler) 1 0.1 0.1 0.1 0.01 0.0001 0.1 0.05 0.5 0.1 0.1 0.1 0.1 0.01 0.01 0.0001 0.0001 0.0001 0.1 0.01 0.0001 0.0005 0.0001 0.0001 0.0005 0.0001 0.00001 0.0001