Alev Kural, Macit Koldaş, Hatice Seval, Ahmet Omma, Namık Yiğit

CRP ile Metabolik Sendrom Arasındaki İlişki

Giriş: İnsülin direnci metabolik sendrom ile ilişkilidir ve kardiyovasküler hastalıklar için risk faktörüdür. C-Reaktif protein (CRP) gelecekteki kardiyovasküler hastalıkların habercisi olan bir proinflamatuar belirteçdir. Biz bu çalışmada insülin direnci ile CRP düzeylerinin ilişkisini ve CRP'nin metabolik sendromda kriter olup olmayacağını araştırdık. Gereç ve Yöntem: Bu çalışmaya metabolik sendrom tanısı almış 63 hasta ile 20 sağlıklı kontrol grubu dahil edildi. Açlık kan glukoz seviyeleri, insülin ve CRP düzeyleri ölçüldü. İnsülin dirençleri (Homeostasis Model Assessment=HOMA-IR) formülü kullanılarak değerlendirildi. Bulgular: Metabolik sendromlu hasta grubu ile kontrol grubu arasında bel çevresi, açlık glukozu, insülin ve CRP değerleri arasında istatistiksel anlamlı farklılıklar vardı.Hasta grubunda açlık glukoz düzeyleri ve CRP arasında (P=0,0001, r=0,3) ve HOMA-IR ile CRP arasında (P=0,007, r=0,29) zayıf fakat anlamlı bir ilişki vardı. Sonuç: CRP'nin metabolik sendromun tanı ve takibinde önemli bir parametre olduğu sonucuna vardık. Anahtar kelimeler: Diabet, Metabolik sendrom, CRP, HOMA, İnsülin direnci, Bel çevresi

Anahtar Kelimeler:

Diabet, Metabolik sendrom, CRP, HOMA, İnsülin direnci, Bel çevresi

The Association Between C - reactive protein and Metabolic Syndrome Components

Background: Insulin resistance is associated with metabolic syndrome and is a risk factor for cardiovascular disease. C-reactive protein (CRP) is an inflammatory marker which is demonstrated as a strong predictor of future cardiovascular events. Material Method: In this study, sixty-three patients who were diagnosed with metabolic syndrome and twenty healthy controls were recruited. Fasting blood glucose, insulin and CRP levels were measured. Homeostasis Model Assessment (HOMA-IR) formula is used to evaluate insulin resistance. We investigated the relationship between insulin resistance and CRP levels and whether CRP is a metabolic syndrome criterion or not. Results: There were statistically significant differences between patients with metabolic syndrome and controls in terms of waist circumference, fasting glucose, insulin and CRP levels. In patients, we found a poor but significant relationship between fasting glucose levels and CRP (P=0.0001, r=0.3) and between HOMA-IR values and CRP (P=0.007, r=0.29). Conclusion: We concluded that CRP may have an important role in the diagnosis and follow-up of metabolic syndrome. Key words: Diabetes, Metabolic syndrome, CRP, HOMA, Insulin resistance, Waist circumference

Keywords:

Diabetes, Metabolic syndrome, CRP, HOMA, Insulin resistance, Waist circumference,

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Corresponding Author: Dr.Alev KURAL
Ataköy 9. kısım A2Blok B Giriş No:92
Bakırköy Istanbul/TURKEY
E-mail : alevkural@hotmail.com
Phone : 212 5294400-1408
Fax: : 212 589 59 58