Akın KAYA, Uğur GÖNÜLLÜ, Deniz KÖKSAL, Ebru ÜNSAL, Hacer SAVAŞ, Barış POYRAZ, Tuğrul ŞİPİT

The value of serum interferon-gamma level in the differential diagnosis of active and inactive pulmonary tuberculosis

İnterferon (IFN)-gama, Mycobacterium tuberculosis’e karşı koruyucu immünitede önemli rol oynamaktadır. Pulmoner tüberkülozlu hastaların etkilenen akciğerlerinde ve kanında IFN-gama düzeylerinin arttığı görülmüştür. Bu çalışmada, serum IFN-gama düzeyinin aktif ve inaktif pulmoner tüberküloz ayırıcı tanısındaki yerinin araştırılması amaçlanmıştır. Çalışmaya yeni tanı almış aktif pulmoner tüberkülozlu 47 hasta, inaktif pulmoner tüberkülozlu 21 hasta ve 20 sağlıklı kontrol dahil edildi. Alınan serum örnekleri IFN-gama analizine kadar -70°C’de saklandı. Ortalama IFN-gama düzeyleri yeni tanı almış aktif pulmoner tüberkülozlu hastalarda 9.3 ± 4.6 pg/mL, inaktif pulmoner tüberkülozlu hastalarda 9.8 ± 3.8 pg/mL ve sağlıklı kontrollerde 10.2 ± 3.4 pg/mL bulundu. Üç grubun IFN-gama düzeyleri arasında istatistiksel olarak anlamlı bir fark bulunmadı (p= 0.4). Serum IFN-gama düzeyi, aktif ve inaktif pulmoner tüberkülozun ayırıcı tanısında değerli bulunmamıştır.

Serum interferon-gama düzeyinin aktif ve inaktif pulmoner tüberküloz ayırıcı tanısındaki değeri

Interferon (IFN)-gamma plays a pivotal role in protective immunity against Mycobacterium tuberculosis. Elevations of IFN-gamma have been found in the affected lung and bloodstream of patients with pulmonary tuberculosis. In the present study, we aimed to investigate the role of serum IFN-gamma level in the differential diagnosis of active and inactive pulmonary tuberculosis. Fourty seven patients with newly diagnosed active pulmonary tuberculosis, 21 patients with inactive pulmonary tuberculosis, and 20 healthy volunteers were enrolled in the study. Serum samples were collected from each subject and stored at - 70°C until the analysis of IFN-gamma. The mean value of IFN-gamma levels were 9.3 ± 4.6 pg/mL in patients with newly diagnosed pulmonary tuberculosis, 9.8 ± 3.8 pg/mL in patients with inactive tuberculosis, and 10.2 ± 3.4 pg/mL in healthy controls. The comparison of IFN-gamma levels of the three groups was not found statistically significant (p= 0.4). Serum IFN-gamma level was not found to be valuable in the differential diagnosis of active and inactive pulmonary tuberculosis.

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