Metin GÜÇLÜ, Ercüment EGE, Esra UZASLAN, Fahir ÖZKALEMKAŞ, Şahsine TOLUNAY, Ahmet URSAVAŞ

Primary pulmonary amyloidosis associated with multiple myeloma

Amiloidoz çözünürlüğü olmayan protein yapısında bir maddenin bir veya birden çok organın ekstraselüler matriksinde depolanması ile karakterize bir sendromdur. Amiloidin solunum yollarını tutması nadir olup, farklı klinik tablolara neden olabilmektedir. Primer idiyopatik amiloidozis düşük insidansı ve değişken klinik bulguları nedeni ile tanı güçlüğü yaratan bir hastalıktır. Bu olgu sunumunda difüz interstisyel infiltrasyon bulguları ile ortaya çıkan ve transbronşiyal biyopsi ile AL tipi amiloidozis tanısı alan bir multipl miyelom olgusunu bildiriyoruz.

Primer pulmoner amiloidozis ile multipl miyelom ilişkisi

Amyloidosis is a syndrome characterized by the deposition of an insoluble proteinaceous material in the extracellular matrix of one or several organs. Respiratory tract involvement with amyloid is rare and deposition of lower respiratory tract has been recognized in a variety of situations with different presentations. Primary idiopathic amyloidosis may be a diagnostic problem because of its low incidence and its variable manifestations. We report herein a case with multiple myeloma presenting diffuse interstitial infiltration, in which pulmonary AL type amyloidosis was diagnosed through transbronchial lung biopsy.

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