Erdoğan ÇETİNKAYA, Hilal ONARAN, Mehmet Akif ÖZGÜL, Oğuzhan ZENGİ, Şule GÜL, Ayşegül GÜNEŞ KIRANKAYA, Nuri TUTAR

The place of YKL-40 in non-small cell lung cancer

Giriş : Primer akciğer kanserinin %80'ini olu şturan küçük hücreli dışı akciğer kanseri (KHDAK)nin sa ğkalım oran ı, tedaviye rağmen%15'ten az olup hala dü şük seyretmektedir. Kanserin biyolojik davran ışı tedaviye ba şlamadan önce belirlenebilirse, bu bilgiler tedaviyi yönlendirme, de ğerlendirme ve klinik çalışmaları planlamada kullan ılabilir. Serum YKL-40 seviyelerinin prognostik de ğerleri birçokkanser tiplerinde incelenmiş ve daha çok agresif klinik gidişi yansıttığı gözlenmiştir. Biz de KHDAKlı hastalarda serum YKL-40 seviye-lerinin kanser evresini belirlemedeki rolünü ara ştırdık.Materyal ve Metod: Yeni tan ı alm ış ve daha önce cerrahi, kemoterapi, radyoterapi, semptomatik tedavi almam ış 49 (%89.1)u erkekve 6 (%10.9)s ı kadın toplam 55 hastan ın venöz kan örneklerinde YKL-40 düzeylerine bak ıldı. Bilgisayarlı tomografi (BT), pozitronemisyon tomografi (PET), kraniyal manyetik rezonans görüntüleme (MRG), bronkoskopi, mediastinoskopi bulgularına dayan ılarakTNM evrelendirilmesi yapıldı. KHDAKlı hastalar erken evre ve ileri evre olarak iki gruba ayrılarak incelendi. Grup A: Evre Ia, Ib, IIa,IIb, Grup B: Evre IIIa, IIIb, IV.Bulgular: Evreler aç ısından erken evre (Grup A) ve ileri evre (Grup B)ye ayrılm ış olan hasta grubumuzda YKL-40 düzeylerini karşıla ştırdığım ızda aralarındaki fark istatistiksel olarak anlamlı bulundu (p< 0.05). YKL-40 düzeyleri ile ya ş aras ında orta derecede (r=0.48; p< 0.001) korelasyon saptandı.Sonuç: YKL-40 düzeylerini ileri evre KHDAK (Evre III-IV) grubunda erken evre (Evre I-II) hasta grubuna göre anlamlı olarak yüksekbulduk. YKL-40 düzeylerinin yüksek bulunmas ı durumunda hastalığın ileri evrede olabilece ği akla getirilmeli ve bu konuda ileri tetkikler yapılmalıdır.

Küçük hücreli d ışı akciğ er kanserinde YKL-40 ın yeri

Introduction: Despite varies treatment options, the survival rate of non-small cell lung cancer (NSCLC) is less than 1%. If biologicalbehaviour of any cancer could be known, the information would potentially tailor the clinical work-up, assesment and treatment.The prognostic value of serum YKL-40 level has been investigated in different types of cancer and showed poor prognostic indicationwith more aggressive clinical course. We studied the role of serum YKL-40 levels in patients with NSCLC to determine the stage.Materials and Methods: Serum YKL-40 levels in venous blood samples of 55 patients was studied. 49 (89.1%) male and 6 (10.9%)female newly diagnosed NSCLC patients whom received neither cancer specific or symptom relieving treatment are enrolled. TNMstaging was determined based on the findings of computerized tomography (CT), positron emission tomography (PET), cranial mag-netic resonance imaging (MRI), bronchoscopy and mediastinoscopy. The patients with NSCLC were divided into two groups; GroupA: stage Ia, Ib, IIa, IIb, Group B: stage IIIa, IIIb and IV.Results: There was a statistical difference in YKL-40 serum levels between groups (Group A, Group B) when compared (p< 0.05).A medium and statistical correlation was found (r= 0.48; p< 0.01)between YKL-40 levels and age.Conclusion: YKL-40 levels in advanced stage NSCLC (stage III, IV)was found to be significantly high compared to early stage. Itshould be kept in mind that when YKL levels are high, higherstages of the disease should be suspected and future tests shouldbe performed.

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